|
eF-site ID
|
1jle-AB |
PDB Code
|
1jle |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE |
Classification
|
TRANSFERASE |
Compound
|
HIV-1 RT, A-CHAIN |
Source
|
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) |
|
Sequence
|
A: |
PISPIETVPVKLKPGMDGPQWPLTEEKIKALVEICTEMEK
EGKISKINPYNTPVFKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINN
ETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPD
IVIYQYMDDLXVGSDLEIGQHRTKIEELRQHLLRWGLTTP
KHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
LVGKLNWASQIYPGIKVRQLXKLLRGTKALTEVIPLTEEA
ELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTY
QIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTES
IVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNT
PPLVKLWYQLEKEPIVGAETFYVDGANRLGKAGYVTNRGR
QKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYAL
GIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIG
GNEQVD
|
B: |
PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKR
TQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRK
YTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTK
ILEPFRKQNPDIVIYQYMDDLCVGSDLEIGQHRTKIEELR
QHLLRWELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNW
ASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAEN
REILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPF
KNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKT
PKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLW
YQLEKEPI
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
111 |
type |
BINDING |
sequence |
V
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
186 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
B |
residue |
187 |
type |
BINDING |
sequence |
L
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
A |
residue |
499 |
type |
SITE |
sequence |
S
|
description |
Cleavage; by viral protease => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
402 |
type |
SITE |
sequence |
W
|
description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
B |
residue |
415 |
type |
SITE |
sequence |
E
|
description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
A |
residue |
1 |
type |
SITE |
sequence |
P
|
description |
Cleavage; by viral protease => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
8)
|
chain |
A |
residue |
402 |
type |
SITE |
sequence |
W
|
description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
9)
|
chain |
A |
residue |
415 |
type |
SITE |
sequence |
E
|
description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
10)
|
chain |
A |
residue |
441 |
type |
SITE |
sequence |
Y
|
description |
Cleavage; by viral protease; partial => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|