eF-site ID 1jle-AB
PDB Code 1jle
Chain A, B

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Title CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
Classification TRANSFERASE
Compound HIV-1 RT, A-CHAIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence A:  PISPIETVPVKLKPGMDGPQWPLTEEKIKALVEICTEMEK
EGKISKINPYNTPVFKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINN
ETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPD
IVIYQYMDDLXVGSDLEIGQHRTKIEELRQHLLRWGLTTP
KHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
LVGKLNWASQIYPGIKVRQLXKLLRGTKALTEVIPLTEEA
ELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTY
QIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTES
IVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNT
PPLVKLWYQLEKEPIVGAETFYVDGANRLGKAGYVTNRGR
QKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYAL
GIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIG
GNEQVD
B:  PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKR
TQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRK
YTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTK
ILEPFRKQNPDIVIYQYMDDLCVGSDLEIGQHRTKIEELR
QHLLRWELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNW
ASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAEN
REILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPF
KNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKT
PKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLW
YQLEKEPI
Description


Functional site

1) chain B
residue 111
type BINDING
sequence V
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 186
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

3) chain B
residue 187
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 499
type SITE
sequence S
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

5) chain B
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

6) chain B
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 1
type SITE
sequence P
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

9) chain A
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

10) chain A
residue 441
type SITE
sequence Y
description Cleavage; by viral protease; partial => ECO:0000250
source Swiss-Prot : SWS_FT_FI6


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