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eF-site ID
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1jle-A |
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PDB Code
|
1jle |
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Chain
|
A |
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click to enlarge
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Title
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CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE |
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Classification
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TRANSFERASE |
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Compound
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HIV-1 RT, A-CHAIN |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) |
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Sequence
|
A: |
PISPIETVPVKLKPGMDGPQWPLTEEKIKALVEICTEMEK
EGKISKINPYNTPVFKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINN
ETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPD
IVIYQYMDDLXVGSDLEIGQHRTKIEELRQHLLRWGLTTP
KHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
LVGKLNWASQIYPGIKVRQLXKLLRGTKALTEVIPLTEEA
ELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTY
QIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTES
IVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNT
PPLVKLWYQLEKEPIVGAETFYVDGANRLGKAGYVTNRGR
QKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYAL
GIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIG
GNEQVD
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Description
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Functional site
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1)
|
chain |
A |
| residue |
1 |
| type |
SITE |
| sequence |
P
|
| description |
Cleavage; by viral protease => ECO:0000250
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| source |
Swiss-Prot : SWS_FT_FI4
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2)
|
chain |
A |
| residue |
402 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
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| source |
Swiss-Prot : SWS_FT_FI5
|
|
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3)
|
chain |
A |
| residue |
415 |
| type |
SITE |
| sequence |
E
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
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| source |
Swiss-Prot : SWS_FT_FI5
|
|
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4)
|
chain |
A |
| residue |
441 |
| type |
SITE |
| sequence |
Y
|
| description |
Cleavage; by viral protease; partial => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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5)
|
chain |
A |
| residue |
499 |
| type |
SITE |
| sequence |
S
|
| description |
Cleavage; by viral protease => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
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