eF-site ID 1jkh-AB PDB Code 1jkh Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ) Classification TRANSFERASE Compound HIV-1 RT, A-CHAIN Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM EKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD EDFRKYTAFTIPSINNETIRYQYNVLPQGWKGSPAIFQSS MTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIE ELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQP IVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLL RGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSK DLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTN DVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWT EYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVD GAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIY LALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIE QLIKKEKVYLAWVPAHKGIGGNEQVDKLVSA B:  IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKE GKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRT QDFWHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFT IPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF RKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLR WGELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQI YPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREIL KEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFK LPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQ Description Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 3) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 4) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 5) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 6) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 7) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 8) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 9) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 10) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 11) chain B residue 138 type sequence E description BINDING SITE FOR RESIDUE EFZ A 999 source : AC1 12) chain B residue 111 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 186 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 187 type BINDING sequence L description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 499 type SITE sequence S description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 441 type SITE sequence Y description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI6

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