eF-site ID 1jkh-AB
PDB Code 1jkh
Chain A, B

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Title CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Classification TRANSFERASE
Compound HIV-1 RT, A-CHAIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence A:  ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM
EKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELN
KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
EDFRKYTAFTIPSINNETIRYQYNVLPQGWKGSPAIFQSS
MTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIE
ELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQP
IVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLL
RGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSK
DLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTN
DVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWT
EYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVD
GAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIY
LALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIE
QLIKKEKVYLAWVPAHKGIGGNEQVDKLVSA
B:  IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKE
GKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRT
QDFWHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFT
IPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF
RKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLR
WGELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQI
YPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREIL
KEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFK
LPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQ
Description


Functional site

1) chain A
residue 100
type
sequence L
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

2) chain A
residue 101
type
sequence K
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

3) chain A
residue 103
type
sequence K
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

4) chain A
residue 106
type
sequence V
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

5) chain A
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

6) chain A
residue 188
type
sequence Y
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

7) chain A
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

8) chain A
residue 234
type
sequence L
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

9) chain A
residue 235
type
sequence H
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

10) chain A
residue 318
type
sequence Y
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

11) chain B
residue 138
type
sequence E
description BINDING SITE FOR RESIDUE EFZ A 999
source : AC1

12) chain B
residue 111
type BINDING
sequence V
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

13) chain B
residue 186
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

14) chain B
residue 187
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 499
type SITE
sequence S
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

16) chain B
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

17) chain B
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

19) chain A
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

20) chain A
residue 441
type SITE
sequence Y
description Cleavage; by viral protease; partial => ECO:0000250
source Swiss-Prot : SWS_FT_FI6


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