eF-site ID 1jkf-B
PDB Code 1jkf
Chain B

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Title Holo 1L-myo-inositol-1-phosphate Synthase
Classification ISOMERASE
Compound myo-inositol-1-phosphate synthase
Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (INO1_YEAST)
Sequence B:  TSVKVVTDKCTYKDNELLTKYSYENAVVTKTASGRFDVTP
TVQDYVFKLDLKKPEKLGIMLIGLGGNNGSTLVASVLANK
HNVEFQTKEGVKQPNYFGSMTQCSTLKLGIDAEGNDVYAP
FNSLLPMVSPNDFVVSGWDINNADLYEAMQRSQVLEYDLQ
QRLKAKMSLVKPLPSIYYPDFIAANQDERANNCINLDEKG
NVTTRGKWTHLQRIRRDIQNFKEENALDKVIVLWTANTER
YVEVSPGVNDTMENLLQSIKNDHEEIAPSTIFAAASILEG
VPYINGSPQNTFVPGLVQLAEHEGTFIAGDDLKSGQTKLK
SVLAQFLVDAGIKPVSIASYNHSKVAMDEYYSELMLGGHN
RISIHNVCEDSLLATPLIIDLLVMTEFCTRVSYKKVDPVK
EDAGKFENFYPVLTFLSYWLKAPLTRPGFHPVNGLNKQRT
ALENFLRLLIGLPSQNELRFEERLL
Description (1)  myo-inositol-1-phosphate synthase (E.C.5.5.1.4)


Functional site
1) chain B
residue 72
type
sequence G
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
2) chain B
residue 74
type
sequence G
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
3) chain B
residue 75
type
sequence G
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
4) chain B
residue 76
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
5) chain B
residue 77
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
6) chain B
residue 148
type
sequence D
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
7) chain B
residue 149
type
sequence I
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
8) chain B
residue 184
type
sequence S
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
9) chain B
residue 194
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
10) chain B
residue 195
type
sequence Q
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
11) chain B
residue 196
type
sequence D
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
12) chain B
residue 197
type
sequence E
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
13) chain B
residue 244
type
sequence T
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
14) chain B
residue 245
type
sequence A
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
15) chain B
residue 246
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
16) chain B
residue 247
type
sequence T
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
17) chain B
residue 296
type
sequence S
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
18) chain B
residue 297
type
sequence P
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
19) chain B
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
20) chain B
residue 321
type
sequence L
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
21) chain B
residue 322
type
sequence K
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
22) chain B
residue 323
type
sequence S
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
23) chain B
residue 442
type
sequence A
description BINDING SITE FOR RESIDUE NAD B 610
source : AC1
24) chain B
residue 298
type catalytic
sequence Q
description 331
source MCSA : MCSA2
25) chain B
residue 347
type catalytic
sequence A
description 331
source MCSA : MCSA2
26) chain B
residue 467
type catalytic
sequence V
description 331
source MCSA : MCSA2
27) chain B
residue 52
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12836703, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1LA2
source Swiss-Prot : SWS_FT_FI1
28) chain B
residue 274
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI10
29) chain B
residue 333
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI10
30) chain B
residue 298
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1P1H
source Swiss-Prot : SWS_FT_FI11
31) chain B
residue 301
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1P1J
source Swiss-Prot : SWS_FT_FI12
32) chain B
residue 332
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H
source Swiss-Prot : SWS_FT_FI13
33) chain B
residue 334
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI14
34) chain B
residue 347
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI15
35) chain B
residue 416
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI17
36) chain B
residue 417
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1K
source Swiss-Prot : SWS_FT_FI18
37) chain B
residue 26
type MOD_RES
sequence L
description Phosphothreonine => ECO:0000269|PubMed:23902760
source Swiss-Prot : SWS_FT_FI19
38) chain B
residue 53
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI2
39) chain B
residue 155
type MOD_RES
sequence Y
description Phosphoserine => ECO:0000269|PubMed:23902760
source Swiss-Prot : SWS_FT_FI20
40) chain B
residue 162
type MOD_RES
sequence Q
description Phosphoserine => ECO:0000269|PubMed:23902760
source Swiss-Prot : SWS_FT_FI20
41) chain B
residue 274
type MOD_RES
sequence E
description Phosphoserine => ECO:0000269|PubMed:23902760
source Swiss-Prot : SWS_FT_FI20
42) chain B
residue 346
type MOD_RES
sequence I
description Phosphoserine => ECO:0007744|PubMed:19779198
source Swiss-Prot : SWS_FT_FI21
43) chain B
residue 225
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI3
44) chain B
residue 54
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI3
45) chain B
residue 55
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI3
46) chain B
residue 126
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI3
47) chain B
residue 223
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI3
48) chain B
residue 162
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI4
49) chain B
residue 163
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI5
50) chain B
residue 176
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:12836703, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1LA2, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1J, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI5
51) chain B
residue 173
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:11779862, ECO:0007744|PDB:1JKF
source Swiss-Prot : SWS_FT_FI6
52) chain B
residue 174
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11779862, ECO:0007744|PDB:1JKF
source Swiss-Prot : SWS_FT_FI6
53) chain B
residue 299
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:11779862, ECO:0007744|PDB:1JKF
source Swiss-Prot : SWS_FT_FI6
54) chain B
residue 222
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:12836703, ECO:0007744|PDB:1LA2
source Swiss-Prot : SWS_FT_FI7
55) chain B
residue 224
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0000269|PubMed:14684747, ECO:0007744|PDB:1JKF, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1P1H, ECO:0007744|PDB:1P1I, ECO:0007744|PDB:1P1K, ECO:0007744|PDB:1RM0
source Swiss-Prot : SWS_FT_FI8
56) chain B
residue 273
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11779862, ECO:0000269|PubMed:12832758, ECO:0007744|PDB:1JKI, ECO:0007744|PDB:1P1H
source Swiss-Prot : SWS_FT_FI9

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