|
|
eF-site ID
|
1jfp-A |
|
PDB Code
|
1jfp |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Structure of bovine rhodopsin (dark adapted) |
|
Classification
|
SIGNALING PROTEIN, MEMBRANE PROTEIN |
|
Compound
|
rhodopsin |
|
Source
|
ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; |
|
|
Sequence
|
A: |
LAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNL
AVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATL
GGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAF
TWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETN
NESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQE
SATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQ
GSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVT
TLCCGKNPLGDDEASTTVSKTETSQVAPA
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
113 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
121 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
122 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
125 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
208 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
6)
|
chain |
A |
| residue |
212 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
7)
|
chain |
A |
| residue |
295 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
8)
|
chain |
A |
| residue |
296 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE RET A 400
|
| source |
: AC1
|
|
|
9)
|
chain |
A |
| residue |
97-110 |
| type |
TOPO_DOM |
| sequence |
TSLHGYFVFGPTGC
|
| description |
Extracellular => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
A |
| residue |
174-202 |
| type |
TOPO_DOM |
| sequence |
GWSRYIPEGMQCSCGIDYYTPHEETNNES
|
| description |
Extracellular => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
A |
| residue |
275-286 |
| type |
TOPO_DOM |
| sequence |
IFTHQGSDFGPI
|
| description |
Extracellular => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
A |
| residue |
296 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-(retinylidene)lysine => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23303210, ECO:0000269|PubMed:27458239, ECO:0000269|PubMed:6870827, ECO:0000305|PubMed:6759163, ECO:0007744|PDB:1F88, ECO:0007744|PDB:1GZM, ECO:0007744|PDB:1HZX, ECO:0007744|PDB:1JFP, ECO:0007744|PDB:2HPY, ECO:0007744|PDB:3C9L, ECO:0007744|PDB:3OAX, ECO:0007744|PDB:3PQR, ECO:0007744|PDB:3PXO, ECO:0007744|PDB:5DYS
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
13)
|
chain |
A |
| residue |
334 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI14
|
|
|
14)
|
chain |
A |
| residue |
338 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI14
|
|
|
15)
|
chain |
A |
| residue |
201 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0007744|PDB:1F88, ECO:0007744|PDB:1HZX
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
16)
|
chain |
A |
| residue |
279 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0007744|PDB:1F88, ECO:0007744|PDB:1HZX
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
17)
|
chain |
A |
| residue |
335 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI15
|
|
|
18)
|
chain |
A |
| residue |
336 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI15
|
|
|
19)
|
chain |
A |
| residue |
340 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI15
|
|
|
20)
|
chain |
A |
| residue |
342 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI15
|
|
|
21)
|
chain |
A |
| residue |
343 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by RK and GRK7 => ECO:0000269|PubMed:1396673, ECO:0000269|PubMed:15111114, ECO:0000269|PubMed:15351781
|
| source |
Swiss-Prot : SWS_FT_FI16
|
|
|
22)
|
chain |
A |
| residue |
322 |
| type |
LIPID |
| sequence |
C
|
| description |
S-palmitoyl cysteine => ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:1512231, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239, ECO:0000269|PubMed:3350146, ECO:0007744|PDB:1HZX, ECO:0007744|PDB:1L9H, ECO:0007744|PDB:2HPY, ECO:0007744|PDB:4X1H, ECO:0007744|PDB:5DYS
|
| source |
Swiss-Prot : SWS_FT_FI17
|
|
|
23)
|
chain |
A |
| residue |
323 |
| type |
LIPID |
| sequence |
C
|
| description |
S-palmitoyl cysteine => ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:1512231, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239, ECO:0000269|PubMed:3350146, ECO:0007744|PDB:1HZX, ECO:0007744|PDB:1L9H, ECO:0007744|PDB:2HPY, ECO:0007744|PDB:4BEY, ECO:0007744|PDB:4PXF, ECO:0007744|PDB:4X1H, ECO:0007744|PDB:5DYS
|
| source |
Swiss-Prot : SWS_FT_FI18
|
|
|
24)
|
chain |
A |
| residue |
62-73 |
| type |
TOPO_DOM |
| sequence |
TVQHKKLRTPLN
|
| description |
Cytoplasmic => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
25)
|
chain |
A |
| residue |
134-152 |
| type |
TOPO_DOM |
| sequence |
ERYVVVCKPMSNFRFGENH
|
| description |
Cytoplasmic => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
26)
|
chain |
A |
| residue |
225-252 |
| type |
TOPO_DOM |
| sequence |
QLVFTVKEAAAQQQESATTQKAEKEVTR
|
| description |
Cytoplasmic => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
27)
|
chain |
A |
| residue |
309-348 |
| type |
TOPO_DOM |
| sequence |
MNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
|
| description |
Cytoplasmic => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
28)
|
chain |
A |
| residue |
74-96 |
| type |
TRANSMEM |
| sequence |
YILLNLAVADLFMVFGGFTTTLY
|
| description |
Helical; Name=2 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
29)
|
chain |
A |
| residue |
111-133 |
| type |
TRANSMEM |
| sequence |
NLEGFFATLGGEIALWSLVVLAI
|
| description |
Helical; Name=3 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
30)
|
chain |
A |
| residue |
153-173 |
| type |
TRANSMEM |
| sequence |
AIMGVAFTWVMALACAAPPLV
|
| description |
Helical; Name=4 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
31)
|
chain |
A |
| residue |
203-224 |
| type |
TRANSMEM |
| sequence |
FVIYMFVVHFIIPLIVIFFCYG
|
| description |
Helical; Name=5 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
32)
|
chain |
A |
| residue |
253-274 |
| type |
TRANSMEM |
| sequence |
MVIIMVIAFLICWLPYAGVAFY
|
| description |
Helical; Name=6 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
33)
|
chain |
A |
| residue |
287-308 |
| type |
TRANSMEM |
| sequence |
FMTIPAFFAKTSAVYNPVIYIM
|
| description |
Helical; Name=7 => ECO:0000269|PubMed:10926528, ECO:0000269|PubMed:11425302, ECO:0000269|PubMed:11972040, ECO:0000269|PubMed:12044163, ECO:0000269|PubMed:15327956, ECO:0000269|PubMed:15491621, ECO:0000269|PubMed:16586416, ECO:0000269|PubMed:16908857, ECO:0000269|PubMed:17060607, ECO:0000269|PubMed:17449675, ECO:0000269|PubMed:17825322, ECO:0000269|PubMed:18563085, ECO:0000269|PubMed:18645239, ECO:0000269|PubMed:18818650, ECO:0000269|PubMed:21389983, ECO:0000269|PubMed:22198838, ECO:0000269|PubMed:23579341, ECO:0000269|PubMed:25205354, ECO:0000269|PubMed:26526852, ECO:0000269|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
34)
|
chain |
A |
| residue |
123-139 |
| type |
prosite |
| sequence |
IALWSLVVLAIERYVVV
|
| description |
G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. IALwSLVVLAIERYVvV
|
| source |
prosite : PS00237
|
|
|
35)
|
chain |
A |
| residue |
290-306 |
| type |
prosite |
| sequence |
IPAFFAKTSAVYNPVIY
|
| description |
OPSIN Visual pigments (opsins) retinal binding site. IPaFfAKTSAvyNPviY
|
| source |
prosite : PS00238
|
|
|
36)
|
chain |
A |
| residue |
113 |
| type |
SITE |
| sequence |
E
|
| description |
Plays an important role in the conformation switch to the active conformation => ECO:0000269|PubMed:21389983, ECO:0000305|PubMed:22198838, ECO:0000305|PubMed:23579341, ECO:0000305|PubMed:27458239
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
|