eF-site ID 1jey-ABCD PDB Code 1jey Chain A, B, C, D click to enlarge Title Crystal Structure of the Ku heterodimer bound to DNA Classification DNA BINDING PROTEIN/DNA Compound DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3') Source Homo sapiens (Human) (1JEY) Sequence A:  GRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYIS KIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGA KRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANL FSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDL RDTGIFLDLMHLKKPGGFDISLFYRDIISVHFEESSKLED LLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKAL KPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQI YGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHY LRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYT PRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFAD DKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENP VLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSL VDEFKELVYPPDY B:  NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQ VFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLML PDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGK KFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFL PFSLGGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISL EGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGS NLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVY CLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKS EGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAV ALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHN YECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVD ALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLL HRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKT LFPLIEAKKK C:  GTTTTTAGTTTATTGGGC D:  GCCCAGCTTTCCCAGCTAATAAACTAAAAAC Description Functional site 1) chain B residue 145 type MOD_RES sequence S description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 266 type MOD_RES sequence S description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 333 type MOD_RES sequence Y description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 288 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI10 5) chain A residue 318 type CROSSLNK sequence R description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI10 6) chain B residue 256 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 259 type MOD_RES sequence I description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 319 type MOD_RES sequence D description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 536 type MOD_RES sequence L description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 196 type CROSSLNK sequence G description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 332 type CROSSLNK sequence E description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 12) chain B residue 533 type CROSSLNK sequence I description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 13) chain B residue 535 type CROSSLNK sequence T description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 52 type MOD_RES sequence Q description Phosphoserine; by PRKDC => ECO:0000269|PubMed:9362500 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 456 type MOD_RES sequence P description Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 16) chain A residue 478 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 521 type MOD_RES sequence L description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI8

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