eF-site ID 1jcn-A PDB Code 1jcn Chain A click to enlarge Title BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP Classification OXIDOREDUCTASE Compound INOSINE MONOPHOSPHATE DEHYDROGENASE I Source Homo sapiens (Human) (IMDH1_HUMAN) Sequence A:  TGYVPEDGLTAQQLFASADDLTYNDFLILPGFIDFIADEV DLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIG FIHHNCTPEFQANEVRKVKNFEQGFITDPVVLSPGIPITE VGIVTSRDIDPRIELVVAPAGVTLKEANEILQRSKKGKLP IVNDCDELVRTDLKKNRDYPLASKDSQKQLLCGAAVGTRE DDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKY PHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQ EVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVV KALALGASTVMMGSLLAATTEAPGEKGSIQKFVPYLIAGI QHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQI Description Functional site 1) chain A residue 68 type sequence S description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 2) chain A residue 322 type sequence R description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 3) chain A residue 328 type sequence G description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 4) chain A residue 329 type sequence S description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 5) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 6) chain A residue 334 type sequence Q description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 7) chain A residue 364 type sequence D description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 8) chain A residue 365 type sequence G description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 9) chain A residue 366 type sequence G description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 10) chain A residue 385 type sequence M description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 11) chain A residue 387 type sequence G description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 12) chain A residue 388 type sequence S description BINDING SITE FOR RESIDUE CPR A 631 source : AC1 13) chain A residue 331 type ACT_SITE sequence C description Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 160 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 15) chain A residue 329 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI5 16) chain A residue 364 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI5 17) chain A residue 387 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI5 18) chain A residue 341 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P50096 source Swiss-Prot : SWS_FT_FI7 19) chain A residue 355 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P50096 source Swiss-Prot : SWS_FT_FI7 20) chain A residue 274 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 324 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 326 type BINDING sequence G description in other chain => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 328 type BINDING sequence G description in other chain => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 331 type BINDING sequence C description in other chain => ECO:0000255|HAMAP-Rule:MF_03156 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 321-333 type prosite sequence LRVGMGCGSICIT description IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGcGSICiT source prosite : PS00487

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