|
|
eF-site ID
|
1jca-ABCD |
|
PDB Code
|
1jca |
|
Chain
|
A, B, C, D |
|
click to enlarge
|
|
|
Title
|
Non-standard Design of Unstable Insulin Analogues with Enhanced Activity |
|
Classification
|
HORMONE/GROWTH FACTOR |
|
Compound
|
insulin a |
|
Source
|
Homo sapiens (Human) (INS_HUMAN) |
|
|
Sequence
|
A: |
GIVEQCCKSICSLYQLENYCN
|
| B: |
FVNQHLCGSHLVEALYLVCGERGFFYTPKT
|
| C: |
GIVEQCCKSICSLYQLENYCN
|
| D: |
VNQHLCGSHLVEALYLVCGERGFFYTPKT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 41
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 41
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 41
|
| source |
: AC1
|
|
|
4)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 42
|
| source |
: AC2
|
|
|
5)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 42
|
| source |
: AC2
|
|
|
6)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 42
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
6-20 |
| type |
prosite |
| sequence |
CCKSICSLYQLENYC
|
| description |
INSULIN Insulin family signature. CCKSiCSlyqLenyC
|
| source |
prosite : PS00262
|
|
|
|