eF-site ID 1j93-A PDB Code 1j93 Chain A click to enlarge Title Crystal Structure and Substrate Binding Modeling of the Uroporphyrinogen-III Decarboxylase from Nicotiana tabacum: Implications for the Catalytic Mechanism Classification LYASE Compound UROPORPHYRINOGEN DECARBOXYLASE Source Nicotiana tabacum (Common tobacco) (DCUP_TOBAC) Sequence A:  TQPLLLDAVRGKEVERPPVWLMRQAGRYMKSYQLLCEKYP LFRDRSENVDLVVEISLQPWKVFRPDGVILFSDILTPLSG MNIPFDIIKGKGPVIFDPLRTAADVEKVREFIPEKSVPYV GEALTILRKEVNNQAAVLGFVGAPFTLASYVVEGGSSKNF TKIKRLAFAEPKVLHALLQKFATSMAKYIRYQADSGAQAV QIFDSWATELSPVDFEEFSLPYLKQIVDSVKLTHPNLPLI LYASGSGGLLERLPLTGVDVVSLDWTVDMADGRRRLGPNV AIQGNVDPGVLFGSKEFITNRINDTVKKAGKGKHILNLGH GIKVGTPEENFAHFFEIAKGLRY Description Functional site 1) chain A residue 212 type sequence F description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 2) chain A residue 214 type sequence S description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 3) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 4) chain A residue 251 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 5) chain A residue 253 type sequence S description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 6) chain A residue 329 type sequence H description BINDING SITE FOR RESIDUE SO4 A 584 source : AC1 7) chain A residue 233 type sequence K description BINDING SITE FOR RESIDUE SO4 A 585 source : AC2 8) chain A residue 233 type sequence K description BINDING SITE FOR RESIDUE SO4 A 585 source : AC2 9) chain A residue 166 type sequence S description BINDING SITE FOR RESIDUE SO4 A 586 source : AC3 10) chain A residue 167 type sequence K description BINDING SITE FOR RESIDUE SO4 A 586 source : AC3 11) chain A residue 168 type sequence N description BINDING SITE FOR RESIDUE SO4 A 586 source : AC3 12) chain A residue 169 type sequence F description BINDING SITE FOR RESIDUE SO4 A 586 source : AC3 13) chain A residue 118 type sequence R description BINDING SITE FOR RESIDUE SO4 A 587 source : AC4 14) chain A residue 118 type sequence R description BINDING SITE FOR RESIDUE SO4 A 587 source : AC4 15) chain A residue 119 type sequence E description BINDING SITE FOR RESIDUE SO4 A 587 source : AC4 16) chain A residue 119 type sequence E description BINDING SITE FOR RESIDUE SO4 A 587 source : AC4 17) chain A residue 189 type sequence K description BINDING SITE FOR RESIDUE SO4 A 587 source : AC4 18) chain A residue 137 type sequence R description BINDING SITE FOR RESIDUE SO4 A 588 source : AC5 19) chain A residue 82 type SITE sequence D description Transition state stabilizer => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 32 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 51 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 81 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 82 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 159 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 214 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 329 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 27-36 type prosite sequence PVWLMRQAGR description UROD_1 Uroporphyrinogen decarboxylase signature 1. PVWLMRQAGR source prosite : PS00906 28) chain A residue 147-163 type prosite sequence LGFVGAPFTLASYVVEG description UROD_2 Uroporphyrinogen decarboxylase signature 2. LGFVGaPFTLasYvv.EG source prosite : PS00907

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