eF-site ID 1j1c-AB PDB Code 1j1c Chain A, B click to enlarge Title Binary complex structure of human tau protein kinase I with ADP Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence A:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI ALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGR DTPALFNFTTQELSSNPPLATILIPPHARIQAAA B:  FGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVI GNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDI KPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWT KVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE LRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHA RIQA Description Functional site 1) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE MG A 431 source : AC1 2) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE MG A 431 source : AC1 3) chain B residue 686 type sequence N description BINDING SITE FOR RESIDUE MG B 931 source : AC2 4) chain B residue 700 type sequence D description BINDING SITE FOR RESIDUE MG B 931 source : AC2 5) chain A residue 65 type sequence G description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 6) chain A residue 70 type sequence V description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 7) chain A residue 83 type sequence A description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 8) chain A residue 85 type sequence K description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 9) chain A residue 110 type sequence V description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 10) chain A residue 133 type sequence D description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 11) chain A residue 134 type sequence Y description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 12) chain A residue 135 type sequence V description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 13) chain A residue 141 type sequence R description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 14) chain A residue 185 type sequence Q description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 15) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 16) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 17) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE ADP A 430 source : AC3 18) chain B residue 562 type sequence I description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 19) chain B residue 565 type sequence G description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 20) chain B residue 570 type sequence V description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 21) chain B residue 583 type sequence A description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 22) chain B residue 585 type sequence K description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 23) chain B residue 610 type sequence V description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 24) chain B residue 633 type sequence D description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 25) chain B residue 634 type sequence Y description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 26) chain B residue 635 type sequence V description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 27) chain B residue 638 type sequence T description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 28) chain B residue 685 type sequence Q description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 29) chain B residue 686 type sequence N description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 30) chain B residue 688 type sequence L description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 31) chain B residue 700 type sequence D description BINDING SITE FOR RESIDUE ADP B 930 source : AC4 32) chain A residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 33) chain B residue 681 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 34) chain A residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 562 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 585 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 716 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI5 40) chain A residue 62-86 type prosite sequence IGNGSFGVVYQAKLCDSGELVAIKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK source prosite : PS00107 41) chain A residue 177-189 type prosite sequence ICHRDIKPQNLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL source prosite : PS00108

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