|
|
eF-site ID
|
1izb-ABCD |
|
PDB Code
|
1izb |
|
Chain
|
A, B, C, D |
|
click to enlarge
|
|
|
Title
|
ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN |
|
Classification
|
HORMONE |
|
Compound
|
INSULIN |
|
Source
|
null (INS_PIG) |
|
|
Sequence
|
A: |
GIVEQCCTSICSLYQLENYCN
|
| B: |
FVNQHLCGSHLVQALYLVCGERGFFYTPKT
|
| C: |
GIVEQCCTSICSLYQLENYCN
|
| D: |
FVNQHLCGSHLVQALYLVCGERGFFYTPKT
|
|
|
Description
|
(1) |
INSULIN MUTANT WITH GLU B 13 REPLACED BY GLN AND WITH GLU D 13 REPLACED BY GLN (E(B 13)Q,E(D 13)Q) COMPLEX WITH ZINC
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 101
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 101
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 101
|
| source |
: AC1
|
|
|
4)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 102
|
| source |
: AC2
|
|
|
5)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 102
|
| source |
: AC2
|
|
|
6)
|
chain |
D |
| residue |
10 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN D 102
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
6-20 |
| type |
prosite |
| sequence |
CCTSICSLYQLENYC
|
| description |
INSULIN Insulin family signature. CCTSiCSlyqLenyC
|
| source |
prosite : PS00262
|
|
|
|