|
|
eF-site ID
|
1ivo-ABCD |
|
PDB Code
|
1ivo |
|
Chain
|
A, B, C, D |
|
click to enlarge
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Title
|
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. |
|
Classification
|
TRANSFERASE/SIGNALING PROTEIN |
|
Compound
|
Epidermal Growth Factor Receptor |
|
Source
|
(EGF_HUMAN) |
|
|
Sequence
|
A: |
EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNL
EITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQ
IIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILH
GAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLG
SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP
PLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHG
SCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEF
KDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP
PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEI
IRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISG
NKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQV
CHALCSPEGCWGPEPRDCVSCRNVSRGRECV
|
| B: |
EKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLE
ITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQI
IRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHG
AVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGS
CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGK
SPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPP
LMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGS
CVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK
DSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPP
LDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEII
RGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGN
KNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVC
HALCSPEGCWGPEPRDCVSCRNVSRGRECV
|
| C: |
ECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQY
RDLKWWE
|
| D: |
ECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQY
RDLKWWE
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
31-42 |
| type |
prosite |
| sequence |
CNCVVGYIGERC
|
| description |
EGF_1 EGF-like domain signature 1. CnCvvGyiGErC
|
| source |
prosite : PS00022
|
|
|
2)
|
chain |
C |
| residue |
31-42 |
| type |
prosite |
| sequence |
CNCVVGYIGERC
|
| description |
EGF_2 EGF-like domain signature 2. CnCvvGYiger....C
|
| source |
prosite : PS01186
|
|
|
3)
|
chain |
A |
| residue |
389 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
4)
|
chain |
B |
| residue |
389 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
5)
|
chain |
A |
| residue |
420 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
6)
|
chain |
B |
| residue |
420 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
7)
|
chain |
A |
| residue |
504 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
8)
|
chain |
B |
| residue |
504 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
9)
|
chain |
A |
| residue |
205 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:21487020
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
B |
| residue |
205 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:21487020
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
A |
| residue |
32 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
B |
| residue |
32 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
13)
|
chain |
A |
| residue |
49 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:20837704, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
14)
|
chain |
B |
| residue |
49 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:20837704, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
15)
|
chain |
A |
| residue |
104 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:8962717
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
16)
|
chain |
B |
| residue |
104 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:8962717
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
17)
|
chain |
A |
| residue |
151 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
18)
|
chain |
B |
| residue |
151 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
19)
|
chain |
A |
| residue |
172 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
20)
|
chain |
B |
| residue |
172 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:3NJP
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
21)
|
chain |
A |
| residue |
328 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
22)
|
chain |
B |
| residue |
328 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
23)
|
chain |
A |
| residue |
337 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
24)
|
chain |
B |
| residue |
337 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
|