eF-site ID 1itq-AB PDB Code 1itq Chain A, B click to enlarge Title HUMAN RENAL DIPEPTIDASE Classification HYDROLASE Compound RENAL DIPEPTIDASE Source (MDP1_HUMAN) Sequence A:  DFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERA NLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVR RTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVAS LIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWAD NWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVS VATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLV KQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGA RAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEA EVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGS CRTHYGYSS B:  DFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERA NLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVR RTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVAS LIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWAD NWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVS VATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLV KQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGA RAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEA EVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGS CRTHYGYSS Description Functional site 1) chain A residue 20 type catalytic sequence H description 168 source MCSA : MCSA1 2) chain A residue 22 type catalytic sequence D description 168 source MCSA : MCSA1 3) chain A residue 125 type catalytic sequence E description 168 source MCSA : MCSA1 4) chain A residue 152 type catalytic sequence H description 168 source MCSA : MCSA1 5) chain A residue 198 type catalytic sequence H description 168 source MCSA : MCSA1 6) chain A residue 219 type catalytic sequence H description 168 source MCSA : MCSA1 7) chain A residue 288 type catalytic sequence D description 168 source MCSA : MCSA1 8) chain B residue 20 type catalytic sequence H description 168 source MCSA : MCSA2 9) chain B residue 22 type catalytic sequence D description 168 source MCSA : MCSA2 10) chain B residue 125 type catalytic sequence E description 168 source MCSA : MCSA2 11) chain B residue 152 type catalytic sequence H description 168 source MCSA : MCSA2 12) chain B residue 198 type catalytic sequence H description 168 source MCSA : MCSA2 13) chain B residue 219 type catalytic sequence H description 168 source MCSA : MCSA2 14) chain B residue 288 type catalytic sequence D description 168 source MCSA : MCSA2 15) chain A residue 124-146 type prosite sequence VEGGHSIDSSLGVLRALYQLGMR description RENAL_DIPEPTIDASE_1 Renal dipeptidase active site. VEGGhsIdsslgvLralYqlGMR source prosite : PS00869 16) chain A residue 20 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 22 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 198 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 219 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 20 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 22 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 198 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 219 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 125 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:32325220 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:32325220 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 230 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 288 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 230 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 288 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 369 type LIPID sequence S description GPI-anchor amidated serine => ECO:0000269|PubMed:2168407 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 369 type LIPID sequence S description GPI-anchor amidated serine => ECO:0000269|PubMed:2168407 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 41 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 35) chain B residue 41 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI5 36) chain A residue 263 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI6 37) chain B residue 263 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI6 38) chain A residue 316 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI7 39) chain B residue 316 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777 source Swiss-Prot : SWS_FT_FI7 40) chain A residue 342 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 41) chain B residue 342 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI8

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