eF-site ID 1inj-A PDB Code 1inj Chain A click to enlarge Title CRYSTAL STRUCTURE OF THE APO FORM OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS Classification TRANSFERASE Compound 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHETASE Source Escherichia coli (strain K12) (ISPD_ECOLI) Sequence A:  HLDVCAVVPAAKQYLSIGNQTILEHSVHALLAHPRVKRVV IAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKA AGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAA PVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLH DCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVT RPEDLALAEFYLT Description Functional site 1) chain A residue 46 type sequence L description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 2) chain A residue 172 type sequence E description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 3) chain A residue 27 type SITE sequence K description Transition state stabilizer => ECO:0000269|PubMed:11427897 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 157 type SITE sequence R description Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 213 type SITE sequence K description Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 102-109 type prosite sequence VLVHDAAR description ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR source prosite : PS01295

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