eF-site ID 1ikf-HL PDB Code 1ikf Chain H, L click to enlarge Title A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX Classification IMMUNE SYSTEM/IMMUNOSUPPRESSANT Compound IGG1-KAPPA R45-45-11 FAB (LIGHT CHAIN) Source (NOR00033) Sequence H:  EVKLVESGGGLVQPGGSLKLSCATSGFTFSDYYMYWVRQN SEKRLEWVAFISNGGGSAFYADIVKGRFTISRDNAKNTLY LQMSRLKSEDTAMYYCTRHTLYDTLYGNYPVWFADWGQGT LVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFP EPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSS RPSETVTCNVAHPASSTKVDKKIVPRDC L:  DIQMTQTTSSLSASLGDRVTISCRASQDISTYLNWYQQKP DGTVKLLIFYTSRLRSGVPSRFSGSGSGTDYSLTISNLEQ EDIATYFCQQGSRIPPTFGGGTKLEILRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRAAC Description (1)  IGG1-KAPPA R45-45-11 FAB (LIGHT CHAIN), IGG1-KAPPA R45-45-11 FAB (HEAVY CHAIN), CYCLOSPORIN A Functional site 1) chain H residue 31 type sequence D description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 2) chain H residue 33 type sequence Y description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 3) chain H residue 35 type sequence Y description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 4) chain H residue 50 type sequence F description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 5) chain H residue 53 type sequence N description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 6) chain H residue 99 type sequence H description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 7) chain H residue 101 type sequence L description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 8) chain H residue 107 type sequence G description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 9) chain H residue 108 type sequence N description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 10) chain H residue 110 type sequence P description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 11) chain H residue 112 type sequence W description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 12) chain L residue 50 type sequence Y description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 13) chain L residue 91 type sequence G description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 14) chain L residue 92 type sequence S description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 15) chain L residue 94 type sequence I description BINDING SITE FOR CHAIN C OF CYCLOSPORIN A source : AC1 16) chain L residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

Display surface Download Links