eF-site ID 1iig-AB PDB Code 1iig Chain A, B click to enlarge Title STRUCTURE OF TRYPANOSOMA BRUCEI BRUCEI TRIOSEPHOSPHATE ISOMERASE COMPLEXED WITH 3-PHOSPHONOPROPIONATE Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE Source ORGANISM_SCIENTIFIC: Trypanosoma brucei brucei; Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ B:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain B residue 311 type sequence N description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 2) chain B residue 313 type sequence K description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 3) chain B residue 395 type sequence H description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 4) chain B residue 467 type sequence E description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 5) chain B residue 472 type sequence I description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 6) chain B residue 473 type sequence G description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 7) chain B residue 513 type sequence S description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 8) chain B residue 532 type sequence L description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 9) chain B residue 534 type sequence G description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 10) chain B residue 535 type sequence G description BINDING SITE FOR RESIDUE 3PP B 600 source : AC1 11) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 12) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 13) chain B residue 311 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 14) chain B residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 15) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 16) chain B residue 395 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 17) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 18) chain B residue 467 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 19) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171

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