eF-site ID 1ifr-A
PDB Code 1ifr
Chain A

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Title Structure of Lamin A/C Globular Domain
Classification IMMUNE SYSTEM
Compound Lamin A/C
Source Homo sapiens (Human) (LAMA_HUMAN)
Sequence A:  GSHRTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKR
QNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTD
LVWKAQNTWGCGNSLRTALINSTGEEVAMRKLV
Description


Functional site

1) chain A
residue 498
type
sequence W
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

2) chain A
residue 503
type
sequence G
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

3) chain A
residue 504
type
sequence A
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

4) chain A
residue 505
type
sequence T
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

5) chain A
residue 506
type
sequence H
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

6) chain A
residue 507
type
sequence S
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

7) chain A
residue 511
type
sequence D
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

8) chain A
residue 513
type
sequence V
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

9) chain A
residue 515
type
sequence K
description BINDING SITE FOR RESIDUE GOL A 600
source : AC1

10) chain A
residue 450
type MOD_RES
sequence K
description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 457
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P48678
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 458
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI3

13) chain A
residue 496
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P48679
source Swiss-Prot : SWS_FT_FI5

14) chain A
residue 510
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P48679
source Swiss-Prot : SWS_FT_FI5

15) chain A
residue 505
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:20068231
source Swiss-Prot : SWS_FT_FI6

16) chain A
residue 450
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI10

17) chain A
residue 470
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI11

18) chain A
residue 486
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI11

19) chain A
residue 533
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI7

20) chain A
residue 463
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI4


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