eF-site ID 1iep-B PDB Code 1iep Chain B click to enlarge Title CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. Classification TRANSFERASE Compound PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL Source Mus musculus (Mouse) (ABL1_MOUSE) Sequence B:  MDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKY SLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV CTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMA TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ Description Functional site 1) chain B residue 360 type sequence I description BINDING SITE FOR RESIDUE CL B 3 source : AC3 2) chain B residue 253 type sequence Y description BINDING SITE FOR RESIDUE CL B 6 source : AC6 3) chain B residue 321 type sequence G description BINDING SITE FOR RESIDUE CL B 6 source : AC6 4) chain B residue 322 type sequence N description BINDING SITE FOR RESIDUE CL B 6 source : AC6 5) chain B residue 248 type sequence L description BINDING SITE FOR RESIDUE STI B 202 source : AC8 6) chain B residue 253 type sequence Y description BINDING SITE FOR RESIDUE STI B 202 source : AC8 7) chain B residue 256 type sequence V description BINDING SITE FOR RESIDUE STI B 202 source : AC8 8) chain B residue 269 type sequence A description BINDING SITE FOR RESIDUE STI B 202 source : AC8 9) chain B residue 271 type sequence K description BINDING SITE FOR RESIDUE STI B 202 source : AC8 10) chain B residue 286 type sequence E description BINDING SITE FOR RESIDUE STI B 202 source : AC8 11) chain B residue 290 type sequence M description BINDING SITE FOR RESIDUE STI B 202 source : AC8 12) chain B residue 299 type sequence V description BINDING SITE FOR RESIDUE STI B 202 source : AC8 13) chain B residue 313 type sequence I description BINDING SITE FOR RESIDUE STI B 202 source : AC8 14) chain B residue 315 type sequence T description BINDING SITE FOR RESIDUE STI B 202 source : AC8 15) chain B residue 318 type sequence M description BINDING SITE FOR RESIDUE STI B 202 source : AC8 16) chain B residue 360 type sequence I description BINDING SITE FOR RESIDUE STI B 202 source : AC8 17) chain B residue 361 type sequence H description BINDING SITE FOR RESIDUE STI B 202 source : AC8 18) chain B residue 380 type sequence A description BINDING SITE FOR RESIDUE STI B 202 source : AC8 19) chain B residue 381 type sequence D description BINDING SITE FOR RESIDUE STI B 202 source : AC8 20) chain B residue 382 type sequence F description BINDING SITE FOR RESIDUE STI B 202 source : AC8 21) chain B residue 363 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 248 type BINDING sequence L description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 316 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 271 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 229 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P42684 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 446 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:9109492 source Swiss-Prot : SWS_FT_FI7 27) chain B residue 253 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P00519 source Swiss-Prot : SWS_FT_FI5 28) chain B residue 257 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P00519 source Swiss-Prot : SWS_FT_FI5 29) chain B residue 413 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P00519 source Swiss-Prot : SWS_FT_FI5 30) chain B residue 393 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:10988075, ECO:0000269|PubMed:12748290 source Swiss-Prot : SWS_FT_FI6

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