eF-site ID 1i7m-D PDB Code 1i7m Chain D click to enlarge Title HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE Classification LYASE Compound S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN Source Homo sapiens (Human) (DCAM_HUMAN) Sequence D:  HFFEGTEKLLEVWFSGSGDLRTIPRSEWDILLKDVQCSII SVTKTDKQEAYVLSE Description Functional site 1) chain D residue 1013 type sequence L description BINDING SITE FOR RESIDUE PUT D 1350 source : AC2 2) chain D residue 1015 type sequence E description BINDING SITE FOR RESIDUE PUT D 1350 source : AC2 3) chain D residue 1065 type sequence L description BINDING SITE FOR RESIDUE CG D 1375 source : AC4 4) chain D residue 1066 type sequence S description BINDING SITE FOR RESIDUE CG D 1375 source : AC4 5) chain D residue 1067 type sequence E description BINDING SITE FOR RESIDUE CG D 1375 source : AC4 6) chain D residue 1008 type ACT_SITE sequence E description Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 1011 type ACT_SITE sequence E description Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 1007 type ACT_SITE sequence F description Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI2 9) chain D residue 1067 type ACT_SITE sequence E description Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI2

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