eF-site ID 1i7d-AB PDB Code 1i7d Chain A, B click to enlarge Title NONCOVALENT COMPLEX OF E.COLI DNA TOPOISOMERASE III WITH AN 8-BASE SINGLE-STRANDED DNA OLIGONUCLEOTIDE Classification ISOMERASE/DNA Compound 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3' Source null (1I7D) Sequence A:  MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTW CIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPS VTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQ LAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCV SALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQT PVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIW QPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYN DKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLY ETHKLITFPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP QPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEA KVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARF LAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEV VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATD GLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHS LPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLY QLIDQAKRTPVRQFRGIVAP B:  CGCAACTT Description Functional site 1) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE CL A 800 source : AC1 2) chain A residue 61 type sequence W description BINDING SITE FOR RESIDUE CL A 800 source : AC1 3) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE CL A 800 source : AC1 4) chain B residue 701 type sequence C description BINDING SITE FOR RESIDUE CL A 800 source : AC1 5) chain B residue 701 type sequence C description BINDING SITE FOR RESIDUE CL A 800 source : AC1 6) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE SO4 A 900 source : AC2 7) chain A residue 29 type sequence F description BINDING SITE FOR RESIDUE SO4 A 900 source : AC2 8) chain A residue 7 type catalytic sequence E description 64 source MCSA : MCSA1 9) chain A residue 8 type catalytic sequence K description 64 source MCSA : MCSA1 10) chain A residue 103 type catalytic sequence D description 64 source MCSA : MCSA1 11) chain A residue 105 type catalytic sequence D description 64 source MCSA : MCSA1 12) chain A residue 328 type catalytic sequence F description 64 source MCSA : MCSA1 13) chain A residue 330 type catalytic sequence R description 64 source MCSA : MCSA1 14) chain A residue 328 type ACT_SITE sequence F description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383, ECO:0000269|PubMed:10574789 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 7 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00953 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 103 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00953 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 105 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00953 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 61 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI3 19) chain A residue 170 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI3 20) chain A residue 178 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI3 21) chain A residue 185 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI3 22) chain A residue 330 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI3

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