eF-site ID 1i79-B PDB Code 1i79 Chain B click to enlarge Title HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[(3-HYDRAZINOPROPYL)METHYLAMINO]ADENOSINE Classification LYASE Compound S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN Source Homo sapiens (Human) (DCAM_HUMAN) Sequence B:  AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKD VQCSIISVTKTDKQEAYVLSE Description Functional site 1) chain B residue 7 type sequence F description BINDING SITE FOR RESIDUE MHZ A 368 source : AC1 2) chain B residue 65 type sequence L description BINDING SITE FOR RESIDUE MHZ A 368 source : AC1 3) chain B residue 66 type sequence S description BINDING SITE FOR RESIDUE MHZ A 368 source : AC1 4) chain B residue 67 type sequence E description BINDING SITE FOR RESIDUE MHZ A 368 source : AC1 5) chain B residue 13 type sequence L description BINDING SITE FOR RESIDUE PUT A 350 source : AC2 6) chain B residue 15 type sequence E description BINDING SITE FOR RESIDUE PUT A 350 source : AC2 7) chain B residue 11 type ACT_SITE sequence E description Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 67 type ACT_SITE sequence E description Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147 source Swiss-Prot : SWS_FT_FI2

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