eF-site ID 1i6v-ABCDE PDB Code 1i6v Chain A, B, C, D, E click to enlarge Title THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX Classification TRANSCRIPTION Compound DNA-DIRECTED RNA POLYMERASE Source ORGANISM_SCIENTIFIC: Thermus aquaticus; Sequence A:  LKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRRILL SSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKEL VVRFLDPKMASTTLILRAEGPKEVRAVDFTPSADVEIMNP DLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRINAI PVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSV TPLEALNQAVAILKEHLNYFANPE B:  ESKLKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRR ILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNL KELVVRFLDPKMASTTLILRAEGPKEVRAVDFTPSADVEI MNPDLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRI NAIPVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTD GSVTPLEALNQAVAILKEHLNYFANPEASS C:  KIKRFGRIREVIPLPPLTEIQVESYKKALQADVPPEKREN VGIQAAFKETFPIEEGDKGKGGLVLDFLEYRIGDPPFSQD ECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHLPLM TEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIAS IIPLPKRGPWIDLEVEASGVVTMKVNKRKFPLVLLLRVLG YDQETLVRELSAYGDLVQGLLDEAVLAMRPEEAMVRLFTL LRPGDPPKKDKALAYLFGLLADPKRYDLGEAGRYKAEEKL GVGLSGRTLVRFEDGEFKDEVFLPTLRYLFALTAGVPGHE VDDIDHLGNRRIRTVGELMADQFRVGLARLARGVRERMVM GSPDTLTPAKLVNSRPLEAALREFFSRSQLSQFKDETNPL SSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICPV ETPEGANIGLITSLAAYARVDALGFIRTPYRRVKNGVVTE EVVYMTASEEDRYTIAQANTPLEGDRIATDRVVARRRGEP VIVAPEEVEFMDVSPKQVFSLNTNLIPFLEHDDANRALMG SNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDG EVVKVDGTRIAVRYEDGRLVHPLRRYARSNQGTAFDQRPR VRVGQRVKKGDLLADGPASEEGFLALGQNVLVAIMPFDGY NFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPERI TRDIPHLSEAALRDLDEEGIVRIGAEVKPGDILVGRTSFK GEQEPSPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVG RLRLRRGDPGVELKPGVREVVRVFVAQKRKLQVGDKLANR HGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNL GQILETHLGLAGYFLGQRYISPVFDGATEPEIKELLAEAF NLYFGKRQGEGFGVDKREKEVLARAEKLGLVSPGKSPEEQ LKELFDLGKVVLYDGRTGEPFEGPIVVGQMFIMKLYHMVE DKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEA YGAAHTLQEMLTIKSDDIEGRNAAYQAIIKGEDVPEPSVP ESFRVLVKELQALALDVQTLDEKDNPVDVFEGL D:  KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVE VTRSIVRRYRMAHIELATPAAHIWFVKDVPSKIATLLDLS ATELEQVLYFNKYIVLDPKAAVLDAVPVEKRQLLTDXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIDARMGAE AIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVV RAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRN NRLKKLLAQGAPEIIIRNEKRMLQEAVDAVIDNGRRGSPV TNPGSERPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVI VVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKAFAPNVK AARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRL GIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPL SSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYY ITQVRKEKKGAGMAFATPEEALAAYERGEVALNAPIVVAG RETSVGRLKFVFANPDEALLAVAHGLLDLQDTVTTRYLGR RLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSL KDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGI DDAVIPEEKQRYLEEADRKLRQIEQAYEMGFLTDRERYDQ VIQLWTETTEKVTQAVFNNFEENYPFNPLYVMAQSGARGN PQQIRQLCGMRGLMQKPSGETFEVPVRSSFREGLTVLEYF ISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREAD CGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAR EVEALGRRLEEGRYLSLEDVHFLIKAAEAGEVREVPVRSP LTCQTRYGVCQKCYGYDLSMARPVSIGEAVGVVAAESIGE PGTQLTMRTGTDITQGLPRVIELFEARRPKAKAVISEIDG VVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYV EAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQ GVKLHDKHIEIVVRQMLKYVEVTDPGDSRLLEGQVLEKWD VEALNERLIAVPVAWKPLLMGVTKSALSTKSWLSAASFQN TTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVR FTQVVDQRTLKAIE E:  MAEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHRFKNTVL EPEERPKMRTLEGLYDDPNAVTWAMKELLTGRLFFGENLV PEDRLQKEMERLYPTEEE Description Functional site 1) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D 1600 source : AC1 2) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D 1600 source : AC1 3) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 1601 source : AC2 4) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 1601 source : AC2 5) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 1601 source : AC2 6) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 1601 source : AC2 7) chain C residue 134 type sequence R description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 8) chain C residue 389 type sequence S description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 9) chain C residue 390 type sequence Q description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 10) chain C residue 391 type sequence L description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 11) chain C residue 392 type sequence S description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 12) chain C residue 393 type sequence Q description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 13) chain C residue 394 type sequence F description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 14) chain C residue 396 type sequence D description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 15) chain C residue 409 type sequence R description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 16) chain C residue 411 type sequence S description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 17) chain C residue 445 type sequence E description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 18) chain C residue 452 type sequence I description BINDING SITE FOR RESIDUE RFP C 1640 source : AC3 19) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166 20) chain D residue 1461 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 1464 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 999 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 1001 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 1003 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 1372 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 1454 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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