eF-site ID 1i4d-ABD PDB Code 1i4d Chain A, B, D click to enlarge Title CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21) Classification SIGNALING PROTEIN Compound ARFAPTIN 2 Source null (RAC1_HUMAN) Sequence A:  SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLL QTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGET LLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAY RTDLEELSESAQATFQAHRDKYEKLRGDVAIKLKFLEENK IKVMHKQLLLFHNAVSAYFAGNQKQLEQ B:  VDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQ HALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLG AVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTD LEESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHK QLLLFHNAVSAYFAGNQKQLEQTLQ D:  QAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYS ANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLIC FSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRD DKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALT QRGLKTVFDEAIRAVLC Description Functional site 1) chain D residue 17 type sequence T description BINDING SITE FOR RESIDUE MG D 201 source : AC1 2) chain D residue 12 type sequence G description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 3) chain D residue 13 type sequence A description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 4) chain D residue 15 type sequence G description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 5) chain D residue 16 type sequence K description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 6) chain D residue 17 type sequence T description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 7) chain D residue 18 type sequence C description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 8) chain D residue 28 type sequence F description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 9) chain D residue 116 type sequence K description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 10) chain D residue 118 type sequence D description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 11) chain D residue 119 type sequence L description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 12) chain D residue 158 type sequence S description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 13) chain D residue 159 type sequence A description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 14) chain D residue 160 type sequence L description BINDING SITE FOR RESIDUE GDP D 200 source : AC2 15) chain D residue 13 type BINDING sequence A description BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR source Swiss-Prot : SWS_FT_FI1 16) chain D residue 60 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR source Swiss-Prot : SWS_FT_FI1 17) chain D residue 30 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR source Swiss-Prot : SWS_FT_FI1 18) chain D residue 159 type BINDING sequence A description BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH source Swiss-Prot : SWS_FT_FI2 19) chain D residue 116 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH source Swiss-Prot : SWS_FT_FI2 20) chain D residue 147 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184 source Swiss-Prot : SWS_FT_FI11 21) chain D residue 166 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198 source Swiss-Prot : SWS_FT_FI12 22) chain D residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 source Swiss-Prot : SWS_FT_FI10 23) chain D residue 32 type MOD_RES sequence Y description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538 source Swiss-Prot : SWS_FT_FI3 24) chain D residue 35 type MOD_RES sequence T description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 source Swiss-Prot : SWS_FT_FI4 25) chain D residue 71 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:10617634 source Swiss-Prot : SWS_FT_FI5 26) chain D residue 32 type CARBOHYD sequence Y description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI9

Display surface Download Links