eF-site ID 1hzj-AB PDB Code 1hzj Chain A, B click to enlarge Title HUMAN UDP-GALACTOSE 4-EPIMERASE: ACCOMMODATION OF UDP-N-ACETYLGLUCOSAMINE WITHIN THE ACTIVE SITE Classification ISOMERASE Compound UDP-GALACTOSE 4-EPIMERASE Source null (GALE_HUMAN) Sequence A:  AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRG GGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYS FMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK FFIEEMIRDLCQADKTWNVVLLRYFNPTGAHASGCIGEDP QGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY IHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMV QAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWT AALGLDRMCEDLWRWQKQNPSGFGT B:  AEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRG GGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYS FMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKA HGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSK FFIEEMIRDLCQADKTWNVVLLRYFNPTGAHASGCIGEDP QGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDY IHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMV QAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWT AALGLDRMCEDLWRWQKQNPSGFGT Description Functional site 1) chain A residue 100 type sequence K description BINDING SITE FOR RESIDUE CL A 950 source : AC1 2) chain A residue 101 type sequence P description BINDING SITE FOR RESIDUE CL A 950 source : AC1 3) chain A residue 102 type sequence L description BINDING SITE FOR RESIDUE CL A 950 source : AC1 4) chain B residue 100 type sequence K description BINDING SITE FOR RESIDUE CL B 951 source : AC2 5) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE CL B 951 source : AC2 6) chain B residue 102 type sequence L description BINDING SITE FOR RESIDUE CL B 951 source : AC2 7) chain A residue 4 type sequence K description BINDING SITE FOR RESIDUE CL A 952 source : AC3 8) chain A residue 80 type sequence Y description BINDING SITE FOR RESIDUE CL A 952 source : AC3 9) chain A residue 81 type sequence S description BINDING SITE FOR RESIDUE CL A 952 source : AC3 10) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 11) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 12) chain A residue 13 type sequence Y description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 13) chain A residue 14 type sequence I description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 14) chain A residue 33 type sequence D description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 15) chain A residue 34 type sequence N description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 16) chain A residue 35 type sequence F description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 17) chain A residue 36 type sequence H description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 18) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 19) chain A residue 65 type sequence M description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 20) chain A residue 66 type sequence D description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 21) chain A residue 67 type sequence I description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 22) chain A residue 88 type sequence F description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 23) chain A residue 89 type sequence A description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 24) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 25) chain A residue 92 type sequence K description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 26) chain A residue 130 type sequence S description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 27) chain A residue 131 type sequence S description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 28) chain A residue 132 type sequence S description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 29) chain A residue 157 type sequence Y description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 30) chain A residue 161 type sequence K description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 31) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 32) chain A residue 188 type sequence P description BINDING SITE FOR RESIDUE NAD A 400 source : AC5 33) chain A residue 94 type sequence V description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 34) chain A residue 132 type sequence S description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 35) chain A residue 134 type sequence T description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 36) chain A residue 187 type sequence N description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 37) chain A residue 206 type sequence N description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 38) chain A residue 207 type sequence N description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 39) chain A residue 208 type sequence L description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 40) chain A residue 223 type sequence L description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 41) chain A residue 224 type sequence N description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 42) chain A residue 225 type sequence V description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 43) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 44) chain A residue 237 type sequence G description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 45) chain A residue 239 type sequence R description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 46) chain A residue 241 type sequence Y description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 47) chain A residue 277 type sequence V description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 48) chain A residue 300 type sequence R description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 49) chain A residue 303 type sequence D description BINDING SITE FOR RESIDUE UD1 A 401 source : AC6 50) chain B residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 51) chain B residue 12 type sequence G description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 52) chain B residue 13 type sequence Y description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 53) chain B residue 14 type sequence I description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 54) chain B residue 33 type sequence D description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 55) chain B residue 34 type sequence N description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 56) chain B residue 36 type sequence H description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 57) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 58) chain B residue 65 type sequence M description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 59) chain B residue 66 type sequence D description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 60) chain B residue 67 type sequence I description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 61) chain B residue 88 type sequence F description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 62) chain B residue 89 type sequence A description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 63) chain B residue 90 type sequence G description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 64) chain B residue 92 type sequence K description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 65) chain B residue 130 type sequence S description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 66) chain B residue 131 type sequence S description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 67) chain B residue 157 type sequence Y description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 68) chain B residue 161 type sequence K description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 69) chain B residue 185 type sequence Y description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 70) chain B residue 186 type sequence F description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 71) chain B residue 188 type sequence P description BINDING SITE FOR RESIDUE NAD B 900 source : AC7 72) chain B residue 92 type sequence K description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 73) chain B residue 94 type sequence V description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 74) chain B residue 132 type sequence S description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 75) chain B residue 157 type sequence Y description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 76) chain B residue 185 type sequence Y description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 77) chain B residue 186 type sequence F description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 78) chain B residue 187 type sequence N description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 79) chain B residue 206 type sequence N description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 80) chain B residue 207 type sequence N description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 81) chain B residue 208 type sequence L description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 82) chain B residue 224 type sequence N description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 83) chain B residue 225 type sequence V description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 84) chain B residue 226 type sequence F description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 85) chain B residue 237 type sequence G description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 86) chain B residue 239 type sequence R description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 87) chain B residue 241 type sequence Y description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 88) chain B residue 300 type sequence R description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 89) chain B residue 303 type sequence D description BINDING SITE FOR RESIDUE UD1 B 901 source : AC8 90) chain A residue 157 type ACT_SITE sequence Y description Proton acceptor => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 157 type ACT_SITE sequence Y description Proton acceptor => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 33 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 33 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 66 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 88 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 92 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 161 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 206 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 224 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 101) chain B residue 239 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 102) chain A residue 66 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 103) chain A residue 88 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 92 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 161 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 106) chain A residue 206 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 107) chain A residue 224 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 108) chain A residue 239 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 109) chain A residue 12 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI2 110) chain B residue 132 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331 source Swiss-Prot : SWS_FT_FI3 111) chain A residue 132 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331 source Swiss-Prot : SWS_FT_FI3 112) chain B residue 185 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10801319 source Swiss-Prot : SWS_FT_FI4 113) chain A residue 185 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10801319 source Swiss-Prot : SWS_FT_FI4 114) chain A residue 300 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI5 115) chain B residue 300 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193 source Swiss-Prot : SWS_FT_FI5

Display surface Download Links