eF-site ID 1hxy-ABCD PDB Code 1hxy Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II Classification IMMUNE SYSTEM/TOXIN Compound HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN Source Homo sapiens (Human) (ETXH_STAAU) Sequence A:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEFDA B:  TRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDS DVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHN YGVGESFTVQRRVEPKVTVYPHNLLVCSVSGFYPGSIEVR WFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEV YTCQVEHPSVTSPLTVEWRA C:  PKYVKQNTLKLAT D:  DLHDKSELTDLALANAYGQYNHPFIKENIKSDEISGEKDL IFRNQGDSGNDLRVKFATADLAQKFKNKNVDIYGASFYYK CEKISENISECLYGGTTLNSEKLAQERVIGANVWVDGIQK ETELIRTNKKNVTLQELDIKIRKILSDKYKIYYKDSEISK GLIEFDMKTPRDYSFDIYDLKGENDYEIDKIYEDNKTLKS DDISHIDVNLYT Description Functional site 1) chain B residue 81 type sequence H description BINDING SITE FOR RESIDUE ZN D 600 source : AC1 2) chain D residue 206 type sequence H description BINDING SITE FOR RESIDUE ZN D 600 source : AC1 3) chain D residue 208 type sequence D description BINDING SITE FOR RESIDUE ZN D 600 source : AC1 4) chain D residue 167 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10986116 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 61 type BINDING sequence W description BINDING => ECO:0000305|PubMed:10986116 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 81 type BINDING sequence H description BINDING => ECO:0000305|PubMed:10986116 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 82 type BINDING sequence N description BINDING => ECO:0000305|PubMed:10986116 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 206 type BINDING sequence H description BINDING => ECO:0000269|PubMed:10986116, ECO:0000269|PubMed:11432818, ECO:0007744|PDB:1EWC, ECO:0007744|PDB:1HXY source Swiss-Prot : SWS_FT_FI2 9) chain A residue 52 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10986116, ECO:0000269|PubMed:11432818, ECO:0007744|PDB:1EWC, ECO:0007744|PDB:1HXY source Swiss-Prot : SWS_FT_FI2 10) chain D residue 208 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11432818, ECO:0007744|PDB:1EWC, ECO:0007744|PDB:1HXY source Swiss-Prot : SWS_FT_FI3 11) chain A residue 161-167 type prosite sequence YDCRVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 12) chain B residue 171-177 type prosite sequence YTCQVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 13) chain A residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 14) chain A residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 15) chain A residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 16) chain A residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 17) chain A residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 18) chain A residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 19) chain A residue 53 type SITE sequence S description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI4 20) chain D residue 130-153 type prosite sequence KKNVTLQELDIKIRKILSDKYKIY description STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KknVtlqeLDikiRkiLsdkykIY source prosite : PS00278

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