eF-site ID 1hxe-HIL PDB Code 1hxe Chain H, I, L click to enlarge Title SERINE PROTEASE Classification HYDROLASEE/HYDROLASE INHIBITOR Compound THROMBIN Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQ I:  DFEEIPGEYL L:  DCGLRPLFEKKSLEDKTERELLESYI Description (1)  THROMBIN, HIRUDIN VARIANT-1 Functional site 1) chain H residue 57 type sequence H description ACTIVE SITE source : ACT 2) chain H residue 102 type sequence D description ACTIVE SITE source : ACT 3) chain H residue 195 type sequence S description ACTIVE SITE source : ACT 4) chain H residue 184 type sequence G description BINDING SITE FOR RESIDUE RB H 550 source : AC1 5) chain H residue 221 type sequence D description BINDING SITE FOR RESIDUE RB H 550 source : AC1 6) chain H residue 224 type sequence K description BINDING SITE FOR RESIDUE RB H 550 source : AC1 7) chain H residue 169 type sequence K description BINDING SITE FOR RESIDUE RB H 551 source : AC2 8) chain H residue 172 type sequence T description BINDING SITE FOR RESIDUE RB H 551 source : AC2 9) chain H residue 204 type sequence P description BINDING SITE FOR RESIDUE RB H 551 source : AC2 10) chain H residue 34 type sequence F description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 11) chain H residue 36 type sequence K description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 12) chain H residue 38 type sequence Q description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 13) chain H residue 65 type sequence L description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 14) chain H residue 73 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 15) chain H residue 74 type sequence T description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 16) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 17) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 18) chain H residue 76 type sequence Y description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 19) chain H residue 82 type sequence I description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 20) chain H residue 84 type sequence M description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 21) chain H residue 153 type sequence S description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-1 source : AC3 22) chain I residue 63 type MOD_RES sequence Y description Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938 source Swiss-Prot : SWS_FT_FI1 23) chain H residue 102 type MOD_RES sequence D description Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938 source Swiss-Prot : SWS_FT_FI1 24) chain H residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938 source Swiss-Prot : SWS_FT_FI1 25) chain H residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 26) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 27) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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