|
|
eF-site ID
|
1hww-A |
|
PDB Code
|
1hww |
|
Chain
|
A |
|
click to enlarge
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Title
|
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH SWAINSONINE |
|
Classification
|
HYDROLASE |
|
Compound
|
ALPHA-MANNOSIDASE II |
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Source
|
(MAN2_DROME) |
|
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Sequence
|
A: |
CQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKY
DPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHI
LSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMK
SIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLK
QFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTH
YSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYD
IPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQN
VAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEW
DVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAE
RAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDR
VLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQH
HDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLT
KPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDIL
PSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEA
QVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLA
TYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKF
GDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHF
KFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKG
KLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEI
VMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYP
IPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRL
ASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSKLHP
AGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDH
PSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTP
EEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPE
VCPMETAAYVSSHS
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
90 |
| type |
catalytic |
| sequence |
H
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
A |
| residue |
92 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
A |
| residue |
204 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
4)
|
chain |
A |
| residue |
341 |
| type |
catalytic |
| sequence |
D
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
5)
|
chain |
A |
| residue |
471 |
| type |
catalytic |
| sequence |
H
|
| description |
793
|
| source |
MCSA : MCSA1
|
|
|
6)
|
chain |
A |
| residue |
204 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Nucleophile => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
90 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
92 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
204 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
471 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|