eF-site ID 1hw5-B PDB Code 1hw5 Chain B click to enlarge Title THE CAP/CRP VARIANT T127L/S128A Classification GENE REGULATION Compound CATABOLITE GENE ACTIVATOR Source Escherichia coli (strain K12) (CRP_ECOLI) Sequence B:  VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLY YIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQ ERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQM ARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHP DGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHG KTIVV Description Functional site 1) chain B residue 49 type sequence V description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 2) chain B residue 61 type sequence L description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 3) chain B residue 62 type sequence S description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 4) chain B residue 70 type sequence I description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 5) chain B residue 71 type sequence G description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 6) chain B residue 72 type sequence E description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 7) chain B residue 73 type sequence L description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 8) chain B residue 82 type sequence R description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 9) chain B residue 83 type sequence S description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 10) chain B residue 84 type sequence A description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 11) chain B residue 86 type sequence V description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 12) chain B residue 123 type sequence R description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 13) chain B residue 127 type sequence L description BINDING SITE FOR RESIDUE CMP B 210 source : AC1 14) chain B residue 135 type sequence A description BINDING SITE FOR RESIDUE CMP A 211 source : AC3 15) chain B residue 136 type sequence F description BINDING SITE FOR RESIDUE CMP A 211 source : AC3 16) chain B residue 179-185 type DNA_BIND sequence SRETVGR description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 127 type BINDING sequence L description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 135 type BINDING sequence A description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 170 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 56 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 71 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 82 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 100 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI5 24) chain B residue 96 type SITE sequence E description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:8978616 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 101 type SITE sequence K description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:15520470, ECO:0000269|PubMed:8978616 source Swiss-Prot : SWS_FT_FI4

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