eF-site ID 1hw5-AB
PDB Code 1hw5
Chain A, B

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Title THE CAP/CRP VARIANT T127L/S128A
Classification GENE REGULATION
Compound CATABOLITE GENE ACTIVATOR
Source null (CRP_ECOLI)
Sequence A:  VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLY
YIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQ
ERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQM
ARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHP
DGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHG
KTIVVYGT
B:  VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLY
YIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQ
ERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQM
ARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHP
DGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHG
KTIVV
Description


Functional site
1) chain B
residue 49
type
sequence V
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
2) chain B
residue 61
type
sequence L
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
3) chain B
residue 62
type
sequence S
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
4) chain B
residue 70
type
sequence I
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
5) chain B
residue 71
type
sequence G
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
6) chain B
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
7) chain B
residue 73
type
sequence L
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
8) chain B
residue 82
type
sequence R
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
9) chain B
residue 83
type
sequence S
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
10) chain B
residue 84
type
sequence A
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
11) chain B
residue 86
type
sequence V
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
12) chain B
residue 123
type
sequence R
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
13) chain B
residue 127
type
sequence L
description BINDING SITE FOR RESIDUE CMP B 210
source : AC1
14) chain A
residue 62
type
sequence S
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
15) chain A
residue 70
type
sequence I
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
16) chain A
residue 71
type
sequence G
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
17) chain A
residue 72
type
sequence E
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
18) chain A
residue 73
type
sequence L
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
19) chain A
residue 82
type
sequence R
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
20) chain A
residue 83
type
sequence S
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
21) chain A
residue 84
type
sequence A
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
22) chain A
residue 86
type
sequence V
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
23) chain A
residue 127
type
sequence L
description BINDING SITE FOR RESIDUE CMP A 210
source : AC2
24) chain A
residue 57
type
sequence K
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
25) chain A
residue 58
type
sequence E
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
26) chain A
residue 170
type
sequence Q
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
27) chain A
residue 173
type
sequence G
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
28) chain A
residue 174
type
sequence Q
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
29) chain A
residue 177
type
sequence G
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
30) chain A
residue 178
type
sequence C
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
31) chain A
residue 179
type
sequence S
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
32) chain A
residue 180
type
sequence R
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
33) chain B
residue 135
type
sequence A
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
34) chain B
residue 136
type
sequence F
description BINDING SITE FOR RESIDUE CMP A 211
source : AC3
35) chain A
residue 100
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:18723842
source Swiss-Prot : SWS_FT_FI5
36) chain B
residue 100
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:18723842
source Swiss-Prot : SWS_FT_FI5
37) chain A
residue 167-190
type prosite
sequence ITRQEIGQIVGCSRETVGRILKML
description HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGqIVGcSreTv.GRiLkmL
source prosite : PS00042
38) chain A
residue 29-45
type prosite
sequence LIHQGEKAETLYYIVKG
description CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. LIhQGEkAEtLYYIvkG
source prosite : PS00888
39) chain A
residue 70-88
type prosite
sequence IGELGLFEEGQERSAWVRA
description CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. IGElGLfeegqe.....RSAwVrA
source prosite : PS00889
40) chain A
residue 179-185
type DNA_BIND
sequence SRETVGR
description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387
source Swiss-Prot : SWS_FT_FI1
41) chain B
residue 179-185
type DNA_BIND
sequence SRETVGR
description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387
source Swiss-Prot : SWS_FT_FI1
42) chain A
residue 56
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
43) chain B
residue 127
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
44) chain B
residue 135
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
45) chain B
residue 170
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
46) chain A
residue 135
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
47) chain A
residue 170
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
48) chain B
residue 56
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
49) chain B
residue 71
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
50) chain B
residue 82
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
51) chain A
residue 71
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
52) chain A
residue 82
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
53) chain A
residue 127
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:11124031, ECO:0000269|PubMed:12202833, ECO:0000269|PubMed:1653449, ECO:0000269|PubMed:2828639, ECO:0000269|PubMed:6286624, ECO:0000269|PubMed:8757802
source Swiss-Prot : SWS_FT_FI2
54) chain A
residue 101
type SITE
sequence K
description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:15520470, ECO:0000269|PubMed:8978616
source Swiss-Prot : SWS_FT_FI4
55) chain B
residue 101
type SITE
sequence K
description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:15520470, ECO:0000269|PubMed:8978616
source Swiss-Prot : SWS_FT_FI4
56) chain A
residue 96
type SITE
sequence E
description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:8978616
source Swiss-Prot : SWS_FT_FI3
57) chain B
residue 96
type SITE
sequence E
description Activating region 2 (AR2); probably contacts the N-terminus of RpoA => ECO:0000269|PubMed:8978616
source Swiss-Prot : SWS_FT_FI3

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