eF-site ID 1hvs-AB PDB Code 1hvs Chain A, B click to enlarge Title STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING Classification HYDROLASE (ACID PROTEASE) Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) (POL_HV1B5) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 2) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 4) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 5) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 6) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 7) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 8) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 9) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 10) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 11) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 12) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 13) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 14) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 15) chain B residue 29 type sequence D description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 16) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 17) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 18) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 19) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 20) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE A77 A 800 source : AC1 21) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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