eF-site ID 1ht3-A PDB Code 1ht3 Chain A click to enlarge Title MERCURY INDUCED MODIFICATIONS IN THE STEREOCHEMISTRY OF THE ACTIVE SITE THROUGH CYS-73 IN A SERINE PROTEASE: CRYSTAL STRUCTURE OF THE COMPLEX OF A PARTIALLY MODIFIED PROTEINASE K WITH MERCURY AT 1.8 A RESOLUTION Classification HYDROLASE Compound PROTEINASE K Source ORGANISM_SCIENTIFIC: Engyodontium album; Sequence A:  AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDT GIEASHPEFEGRAQMVKTYYYSSRDGNGHGTHCAGTVGSR TYGVVKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNN RNCPKGVVASLSLGGGYSSSVNSAAARLQSSGVMVAVAAG NNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTL GKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA Description (1)  PROTEINASE K Functional site 1) chain A residue 72 type sequence H description BINDING SITE FOR RESIDUE HG A 280 source : AC1 2) chain A residue 73 type sequence C description BINDING SITE FOR RESIDUE HG A 280 source : AC1 3) chain A residue 225 type sequence M description BINDING SITE FOR RESIDUE HG A 280 source : AC1 4) chain A residue 39 type sequence D description BINDING SITE FOR RESIDUE HG A 281 source : AC2 5) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE HG A 281 source : AC2 6) chain A residue 73 type sequence C description BINDING SITE FOR RESIDUE HG A 281 source : AC2 7) chain A residue 175 type sequence P description BINDING SITE FOR RESIDUE CA A 282 source : AC3 8) chain A residue 177 type sequence V description BINDING SITE FOR RESIDUE CA A 282 source : AC3 9) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE CA A 282 source : AC3 10) chain A residue 39 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 69 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 224 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 16 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 14) chain A residue 175 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 15) chain A residue 177 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 16) chain A residue 200 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 17) chain A residue 260 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 18) chain A residue 35-46 type prosite sequence VYVIDTGIEASH description SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VYVIDTGIeasH source prosite : PS00136 19) chain A residue 69-79 type prosite sequence HGTHCAGTVGS description SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThCAGtVGS source prosite : PS00137 20) chain A residue 222-232 type prosite sequence GTSMATPHVAG description SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAtPhVAG source prosite : PS00138

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