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|
eF-site ID
|
1hrn-B |
|
PDB Code
|
1hrn |
|
Chain
|
B |
|
click to enlarge
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Title
|
HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
|
RENIN |
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Source
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(RENI_HUMAN) |
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Sequence
|
B: |
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN
VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY
STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE
FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN
RDSESLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMK
GVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEAL
GAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVF
QESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE
FDRRNNRIGFALAR
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Description
|
(1) |
RENIN COMPLEXED WITH POLYHYDROXYMONOAMIDE INHIBITOR BILA 980
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
32 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000269|PubMed:20927107
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
B |
| residue |
215 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000269|PubMed:20927107
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
-1 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
67 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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|
|