eF-site ID 1hrn-A PDB Code 1hrn Chain A click to enlarge Title HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS Classification HYDROLASE/HYDROLASE INHIBITOR Compound RENIN Source (RENI_HUMAN) Sequence A:  GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN RDSENSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM KGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEA LGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYV FQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYT EFDRRNNRIGFALAR Description (1)  RENIN COMPLEXED WITH POLYHYDROXYMONOAMIDE INHIBITOR BILA 980 Functional site 1) chain A residue 29-40 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 2) chain A residue 212-223 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 3) chain A residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 5) chain A residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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