|
|
eF-site ID
|
1hqx-B |
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PDB Code
|
1hqx |
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Chain
|
B |
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click to enlarge
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Title
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R308K ARGINASE VARIANT |
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Classification
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HYDROLASE |
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Compound
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ARGINASE |
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Source
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(ARGI1_RAT) |
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Sequence
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B: |
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEY
NVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVA
ETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDA
HTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWV
TPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDK
LGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATG
TPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKT
PEEVTRTVNTAVALTLSCFGTKKEGNHKPETDYL
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
101 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 502
|
| source |
: AC3
|
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2)
|
chain |
B |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 502
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| source |
: AC3
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3)
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chain |
B |
| residue |
128 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 502
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| source |
: AC3
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4)
|
chain |
B |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 502
|
| source |
: AC3
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|
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5)
|
chain |
B |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 503
|
| source |
: AC4
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|
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6)
|
chain |
B |
| residue |
126 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE MN B 503
|
| source |
: AC4
|
|
|
7)
|
chain |
B |
| residue |
232 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 503
|
| source |
: AC4
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|
|
8)
|
chain |
B |
| residue |
234 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MN B 503
|
| source |
: AC4
|
|
|
9)
|
chain |
B |
| residue |
246 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE MN B 503
|
| source |
: AC4
|
|
|
10)
|
chain |
B |
| residue |
281 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:22673903
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| source |
Swiss-Prot : SWS_FT_FI14
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|
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11)
|
chain |
B |
| residue |
101 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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12)
|
chain |
B |
| residue |
17 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
|
| source |
Swiss-Prot : SWS_FT_FI10
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|
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13)
|
chain |
B |
| residue |
75 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q61176
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| source |
Swiss-Prot : SWS_FT_FI10
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|
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14)
|
chain |
B |
| residue |
62 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:22673903
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| source |
Swiss-Prot : SWS_FT_FI11
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|
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15)
|
chain |
B |
| residue |
72 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q61176
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| source |
Swiss-Prot : SWS_FT_FI12
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|
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16)
|
chain |
B |
| residue |
163 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
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| source |
Swiss-Prot : SWS_FT_FI13
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|
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17)
|
chain |
B |
| residue |
217 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P05089
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| source |
Swiss-Prot : SWS_FT_FI13
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|
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18)
|
chain |
B |
| residue |
124 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI2
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19)
|
chain |
B |
| residue |
126 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
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| source |
Swiss-Prot : SWS_FT_FI2
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20)
|
chain |
B |
| residue |
128 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8N, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA
|
| source |
Swiss-Prot : SWS_FT_FI3
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|
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21)
|
chain |
B |
| residue |
183 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0007744|PDB:1T5G
|
| source |
Swiss-Prot : SWS_FT_FI5
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|
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22)
|
chain |
B |
| residue |
232 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8Q, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
23)
|
chain |
B |
| residue |
234 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10542097, ECO:0000269|PubMed:12820884, ECO:0000269|PubMed:15315440, ECO:0000269|PubMed:16266687, ECO:0000269|PubMed:8849731, ECO:0000269|PubMed:9265637, ECO:0007744|PDB:1D3V, ECO:0007744|PDB:1HQ5, ECO:0007744|PDB:1HQF, ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH, ECO:0007744|PDB:1HQX, ECO:0007744|PDB:1P8M, ECO:0007744|PDB:1P8O, ECO:0007744|PDB:1P8P, ECO:0007744|PDB:1P8R, ECO:0007744|PDB:1P8S, ECO:0007744|PDB:1R1O, ECO:0007744|PDB:1RLA, ECO:0007744|PDB:1T4P, ECO:0007744|PDB:1T4R, ECO:0007744|PDB:1T4S, ECO:0007744|PDB:1T4T, ECO:0007744|PDB:1T5F, ECO:0007744|PDB:1T5G, ECO:0007744|PDB:1TA1, ECO:0007744|PDB:1TBH, ECO:0007744|PDB:1TBJ, ECO:0007744|PDB:1TBL, ECO:0007744|PDB:1ZPE, ECO:0007744|PDB:1ZPG, ECO:0007744|PDB:2RLA, ECO:0007744|PDB:3E8Q, ECO:0007744|PDB:3E8Z, ECO:0007744|PDB:3E9B, ECO:0007744|PDB:3RLA, ECO:0007744|PDB:4RLA, ECO:0007744|PDB:5RLA
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
24)
|
chain |
B |
| residue |
246 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250|UniProtKB:P53608
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
25)
|
chain |
B |
| residue |
277 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P78540
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
26)
|
chain |
B |
| residue |
137 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0007744|PDB:1HQG, ECO:0007744|PDB:1HQH
|
| source |
Swiss-Prot : SWS_FT_FI4
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