eF-site ID 1hov_4-A
PDB Code 1hov
Model 4
Chain A

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Title SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound MATRIX METALLOPROTEINASE-2
Source Homo sapiens (Human) (MMP2_HUMAN)
Sequence A:  MYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAF
QVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKD
GLLAHAFAPGTGVGGDSHFDDDELWTNTSANYSLFLVAAH
EFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQE
LYG
Description


Functional site

1) chain A
residue 70
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 165
source : AC1

2) chain A
residue 72
type
sequence D
description BINDING SITE FOR RESIDUE ZN A 165
source : AC1

3) chain A
residue 85
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 165
source : AC1

4) chain A
residue 98
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 165
source : AC1

5) chain A
residue 120
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 166
source : AC2

6) chain A
residue 124
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 166
source : AC2

7) chain A
residue 130
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 166
source : AC2

8) chain A
residue 77
type
sequence D
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

9) chain A
residue 78
type
sequence G
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

10) chain A
residue 79
type
sequence K
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

11) chain A
residue 80
type
sequence D
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

12) chain A
residue 82
type
sequence L
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

13) chain A
residue 100
type
sequence D
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

14) chain A
residue 103
type
sequence E
description BINDING SITE FOR RESIDUE CA A 167
source : AC3

15) chain A
residue 60
type
sequence D
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

16) chain A
residue 92
type
sequence G
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

17) chain A
residue 93
type
sequence V
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

18) chain A
residue 94
type
sequence G
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

19) chain A
residue 95
type
sequence G
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

20) chain A
residue 96
type
sequence D
description BINDING SITE FOR RESIDUE CA A 168
source : AC4

21) chain A
residue 81
type
sequence G
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

22) chain A
residue 82
type
sequence L
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

23) chain A
residue 83
type
sequence L
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

24) chain A
residue 84
type
sequence A
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

25) chain A
residue 85
type
sequence H
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

26) chain A
residue 120
type
sequence H
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

27) chain A
residue 121
type
sequence E
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

28) chain A
residue 124
type
sequence H
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

29) chain A
residue 130
type
sequence H
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

30) chain A
residue 136
type
sequence A
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

31) chain A
residue 137
type
sequence L
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

32) chain A
residue 139
type
sequence A
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

33) chain A
residue 141
type
sequence I
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

34) chain A
residue 142
type
sequence Y
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

35) chain A
residue 143
type
sequence T
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

36) chain A
residue 145
type
sequence T
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

37) chain A
residue 148
type
sequence F
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

38) chain A
residue 149
type
sequence R
description BINDING SITE FOR RESIDUE I52 A 800
source : AC5

39) chain A
residue 26
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI1

40) chain A
residue 101
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI1

41) chain A
residue 60
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI2

42) chain A
residue 92
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI2

43) chain A
residue 70
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI3

44) chain A
residue 72
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI3

45) chain A
residue 85
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI3

46) chain A
residue 98
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI3

47) chain A
residue 77
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

48) chain A
residue 78
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

49) chain A
residue 94
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

50) chain A
residue 96
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

51) chain A
residue 100
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

52) chain A
residue 103
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU
source Swiss-Prot : SWS_FT_FI4

53) chain A
residue 117-126
type prosite
sequence VAAHEFGHAM
description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAM
source prosite : PS00142


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