eF-site ID 1hov_4-A PDB Code 1hov Model 4 Chain A click to enlarge Title SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 Classification HYDROLASE/HYDROLASE INHIBITOR Compound MATRIX METALLOPROTEINASE-2 Source Homo sapiens (Human) (MMP2_HUMAN) Sequence A:  MYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAF QVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKD GLLAHAFAPGTGVGGDSHFDDDELWTNTSANYSLFLVAAH EFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQE LYG Description Functional site 1) chain A residue 70 type sequence H description BINDING SITE FOR RESIDUE ZN A 165 source : AC1 2) chain A residue 72 type sequence D description BINDING SITE FOR RESIDUE ZN A 165 source : AC1 3) chain A residue 85 type sequence H description BINDING SITE FOR RESIDUE ZN A 165 source : AC1 4) chain A residue 98 type sequence H description BINDING SITE FOR RESIDUE ZN A 165 source : AC1 5) chain A residue 120 type sequence H description BINDING SITE FOR RESIDUE ZN A 166 source : AC2 6) chain A residue 124 type sequence H description BINDING SITE FOR RESIDUE ZN A 166 source : AC2 7) chain A residue 130 type sequence H description BINDING SITE FOR RESIDUE ZN A 166 source : AC2 8) chain A residue 77 type sequence D description BINDING SITE FOR RESIDUE CA A 167 source : AC3 9) chain A residue 78 type sequence G description BINDING SITE FOR RESIDUE CA A 167 source : AC3 10) chain A residue 79 type sequence K description BINDING SITE FOR RESIDUE CA A 167 source : AC3 11) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE CA A 167 source : AC3 12) chain A residue 82 type sequence L description BINDING SITE FOR RESIDUE CA A 167 source : AC3 13) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE CA A 167 source : AC3 14) chain A residue 103 type sequence E description BINDING SITE FOR RESIDUE CA A 167 source : AC3 15) chain A residue 60 type sequence D description BINDING SITE FOR RESIDUE CA A 168 source : AC4 16) chain A residue 92 type sequence G description BINDING SITE FOR RESIDUE CA A 168 source : AC4 17) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE CA A 168 source : AC4 18) chain A residue 94 type sequence G description BINDING SITE FOR RESIDUE CA A 168 source : AC4 19) chain A residue 95 type sequence G description BINDING SITE FOR RESIDUE CA A 168 source : AC4 20) chain A residue 96 type sequence D description BINDING SITE FOR RESIDUE CA A 168 source : AC4 21) chain A residue 81 type sequence G description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 22) chain A residue 82 type sequence L description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 23) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 24) chain A residue 84 type sequence A description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 25) chain A residue 85 type sequence H description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 26) chain A residue 120 type sequence H description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 27) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 28) chain A residue 124 type sequence H description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 29) chain A residue 130 type sequence H description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 30) chain A residue 136 type sequence A description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 31) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 32) chain A residue 139 type sequence A description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 33) chain A residue 141 type sequence I description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 34) chain A residue 142 type sequence Y description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 35) chain A residue 143 type sequence T description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 36) chain A residue 145 type sequence T description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 37) chain A residue 148 type sequence F description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 38) chain A residue 149 type sequence R description BINDING SITE FOR RESIDUE I52 A 800 source : AC5 39) chain A residue 121 type catalytic sequence E description Annotated By Reference To The Literature 1hfs source CSA : CSA1 40) chain A residue 138 type catalytic sequence M description Annotated By Reference To The Literature 1hfs source CSA : CSA1 41) chain A residue 121 type catalytic sequence E description Annotated By Reference To The Literature 1hfs source CSA : CSA2 42) chain A residue 120 type catalytic sequence H description 906 source MCSA : MCSA1 43) chain A residue 121 type catalytic sequence E description 906 source MCSA : MCSA1 44) chain A residue 124 type catalytic sequence H description 906 source MCSA : MCSA1 45) chain A residue 130 type catalytic sequence H description 906 source MCSA : MCSA1 46) chain A residue 117-126 type prosite sequence VAAHEFGHAM description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAM source prosite : PS00142

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