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eF-site ID
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1hni-B |
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PDB Code
|
1hni |
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Chain
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B |
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click to enlarge
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Title
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STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION |
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Classification
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NUCLEOTIDYLTRANSFERASE |
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Compound
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HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66) |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1BR) |
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Sequence
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B: |
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWY
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Description
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Functional site
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1)
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chain |
B |
| residue |
1 |
| type |
SITE |
| sequence |
P
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| description |
Cleavage; by viral protease => ECO:0000250
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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2)
|
chain |
B |
| residue |
111 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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4)
|
chain |
B |
| residue |
187 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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5)
|
chain |
B |
| residue |
402 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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6)
|
chain |
B |
| residue |
415 |
| type |
SITE |
| sequence |
E
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
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