eF-site ID 1hni-AB
PDB Code 1hni
Chain A, B

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Title STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION
Classification NUCLEOTIDYLTRANSFERASE
Compound HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66)
Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1BR)
Sequence A:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF
YVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQ
IIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRK
B:  PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF
QSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLS
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYD
PSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWY
Description


Functional site

1) chain A
residue 100
type
sequence L
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

2) chain A
residue 101
type
sequence K
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

3) chain A
residue 106
type
sequence V
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

4) chain A
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

5) chain A
residue 181
type
sequence Y
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

6) chain A
residue 188
type
sequence Y
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

7) chain A
residue 189
type
sequence V
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

8) chain A
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

9) chain A
residue 229
type
sequence W
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

10) chain A
residue 318
type
sequence Y
description BINDING SITE FOR RESIDUE AAA A 559
source : AC1

11) chain A
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization
source Swiss-Prot : SWS_FT_FI4

12) chain A
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization
source Swiss-Prot : SWS_FT_FI4

13) chain B
residue 1
type SITE
sequence P
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 479
type SITE
sequence L
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 499
type SITE
sequence S
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 550
type SITE
sequence K
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

17) chain B
residue 111
type BINDING
sequence V
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

18) chain B
residue 186
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

19) chain B
residue 187
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

21) chain B
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

22) chain A
residue 441
type SITE
sequence Y
description Cleavage; by viral protease; partial
source Swiss-Prot : SWS_FT_FI5


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