eF-site ID 1hmv-B
PDB Code 1hmv
Chain B

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Title THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Classification NUCLEOTIDYLTRANSFERASE
Compound HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66)
Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1)
Sequence B:  IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKE
GKISKIGPENPYNTPVFAIKKWRKLVDFRELNKRTQDFWE
VQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTA
FTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILE
PFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHL
LRHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYP
GIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKE
PVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTG
KYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLP
IQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWY
Description


Functional site

1) chain B
residue 244-261
type ZN_FING
sequence IVLPEKDSWTVNDIQKLV
description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047
source Swiss-Prot : SWS_FT_FI2

2) chain B
residue 358
type ACT_SITE
sequence R
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029
source Swiss-Prot : SWS_FT_FI3

3) chain B
residue 54
type SITE
sequence N
description Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

4) chain B
residue 273
type SITE
sequence G
description Cleavage; by viral protease
source Swiss-Prot : SWS_FT_FI7

5) chain B
residue 333
type SITE
sequence G
description Cleavage; by viral protease
source Swiss-Prot : SWS_FT_FI7

6) chain B
residue 242
type MOD_RES
sequence Q
description Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034
source Swiss-Prot : SWS_FT_FI9

7) chain B
residue 196
type SITE
sequence G
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

8) chain B
residue 210
type SITE
sequence L
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

9) chain B
residue 265
type SITE
sequence N
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI6


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