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eF-site ID
|
1hmv-A |
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PDB Code
|
1hmv |
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Chain
|
A |
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click to enlarge
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Title
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THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
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Classification
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NUCLEOTIDYLTRANSFERASE |
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Compound
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HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66) |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) |
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Sequence
|
A: |
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTE
MEKEGKISKIGPENPYNTPVFAIVDFRELNKRTQDFWEVQ
LGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFT
IPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDI
VIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPD
KKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQ
KLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEE
AELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWT
YQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTE
SIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVN
TPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYV
TNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTD
SQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPA
HKGIGGNEQVDKLVSA
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Description
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Functional site
|
|
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1)
|
chain |
A |
| residue |
443 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG B 501
|
| source |
: AC1
|
|
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2)
|
chain |
A |
| residue |
478 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE MG B 501
|
| source |
: AC1
|
|
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3)
|
chain |
A |
| residue |
498 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG B 501
|
| source |
: AC1
|
|
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4)
|
chain |
A |
| residue |
220 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
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5)
|
chain |
A |
| residue |
242 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034
|
| source |
Swiss-Prot : SWS_FT_FI10
|
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|
|