eF-site ID 1hkc-A
PDB Code 1hkc
Chain A

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Title RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
Classification PHOSPHOTRANSFERASE
Compound D-GLUCOSE 6-PHOSPHOTRANSFERASE
Source (HXK1_HUMAN)
Sequence A:  DDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRV
QVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLG
DFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRF
KASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMM
TCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM
CINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEK
MVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFN
TSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVC
TIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGS
LYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAM
VTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEM
ELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGG
TNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF
DHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGI
LITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVV
NDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEM
VEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVNEYSLN
AGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISET
LKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDD
SILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLN
VTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSED
GSGKGAALITAVGVRLRTE
Description


Functional site
1) chain A
residue 172
type
sequence T
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
2) chain A
residue 173
type
sequence K
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
3) chain A
residue 209
type
sequence D
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
4) chain A
residue 235
type
sequence N
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
5) chain A
residue 260
type
sequence E
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
6) chain A
residue 291
type
sequence Q
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
7) chain A
residue 294
type
sequence E
description GLUCOSE BINDING SITE IN N-TERMINAL DOMAIN.
source : GLN
8) chain A
residue 88
type
sequence S
description PHOSPHATE BINDING SITE IN N-TERMINAL DOMAIN.
source : PIN
9) chain A
residue 232
type
sequence T
description PHOSPHATE BINDING SITE IN N-TERMINAL DOMAIN.
source : PIN
10) chain A
residue 415
type
sequence S
description PHOSPHATE BINDING SITE IN N-TERMINAL DOMAIN.
source : PIN
11) chain A
residue 680
type
sequence T
description PHOSPHATE BINDING SITE IN C-TERMINAL DOMAIN.
source : PIC
12) chain A
residue 863
type
sequence T
description PHOSPHATE BINDING SITE IN C-TERMINAL DOMAIN.
source : PIC
13) chain A
residue 242
type
sequence L
description METAL ION BINDING SITE IN N-TERMINAL DOMAIN.
source : MEN
14) chain A
residue 245
type
sequence I
description METAL ION BINDING SITE IN N-TERMINAL DOMAIN.
source : MEN
15) chain A
residue 248
type
sequence V
description METAL ION BINDING SITE IN N-TERMINAL DOMAIN.
source : MEN
16) chain A
residue 250
type
sequence G
description METAL ION BINDING SITE IN N-TERMINAL DOMAIN.
source : MEN
17) chain A
residue 690
type
sequence M
description METAL ION BINDING SITE IN C-TERMINAL DOMAIN.
source : MEC
18) chain A
residue 693
type
sequence V
description METAL ION BINDING SITE IN C-TERMINAL DOMAIN.
source : MEC
19) chain A
residue 696
type
sequence V
description METAL ION BINDING SITE IN C-TERMINAL DOMAIN.
source : MEC
20) chain A
residue 698
type
sequence G
description METAL ION BINDING SITE IN C-TERMINAL DOMAIN.
source : MEC
21) chain A
residue 150-175
type prosite
sequence VGFTFSFPCQQSKIDEAILITWTKRF
description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcqqskIDeaiLitWTKrF
source prosite : PS00378
22) chain A
residue 598-623
type prosite
sequence LGFTFSFPCQQTSLDAGILITWTKGF
description HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcqqskIDeaiLitWTKrF
source prosite : PS00378
23) chain A
residue 620
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10
24) chain A
residue 656
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10
25) chain A
residue 682
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10
26) chain A
residue 708
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10
27) chain A
residue 742
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI10
28) chain A
residue 747
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1DGK
source Swiss-Prot : SWS_FT_FI12
29) chain A
residue 784
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1DGK
source Swiss-Prot : SWS_FT_FI12
30) chain A
residue 539
type catalytic
sequence R
description 696
source MCSA : MCSA1
31) chain A
residue 603
type catalytic
sequence S
description 696
source MCSA : MCSA1
32) chain A
residue 657
type catalytic
sequence D
description 696
source MCSA : MCSA1
33) chain A
residue 30
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI1
34) chain A
residue 425
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI1
35) chain A
residue 84
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKC
source Swiss-Prot : SWS_FT_FI2
36) chain A
residue 863
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKC
source Swiss-Prot : SWS_FT_FI2
37) chain A
residue 155
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI3
38) chain A
residue 345
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0007744|PDB:1QHA
source Swiss-Prot : SWS_FT_FI7
39) chain A
residue 603
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI9
40) chain A
residue 657
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI11
41) chain A
residue 897
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI13
42) chain A
residue 337
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P05708
source Swiss-Prot : SWS_FT_FI15
43) chain A
residue 172
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4
44) chain A
residue 208
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4
45) chain A
residue 235
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4
46) chain A
residue 260
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4
47) chain A
residue 291
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI4
48) chain A
residue 209
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI5
49) chain A
residue 232
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6
50) chain A
residue 413
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6
51) chain A
residue 449
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6
52) chain A
residue 680
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6
53) chain A
residue 861
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
source Swiss-Prot : SWS_FT_FI6
54) chain A
residue 532
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
source Swiss-Prot : SWS_FT_FI8

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