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eF-site ID
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1he8-A |
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PDB Code
|
1he8 |
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Chain
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A |
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click to enlarge
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Title
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Ras G12V - PI 3-kinase gamma complex |
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Classification
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KINASE/HYDROLASE |
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Compound
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PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM |
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Source
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(RASH_MSVNS) |
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Sequence
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A: |
SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTP
RMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIK
IHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPE
SQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEI
HVVLDTPPDPALDEVRKESLWDCDRKFRVKIRGIDIPVLP
LTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSI
KIKDLPKGALLNLQIYCKVRLLYYVNLLLIDHRFLLRRGE
YVLHMWQISNADKLTSATNPDKENSMSISILLDNYCHPIS
ALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLR
SEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIE
MLQKVTLDIKSLSSQVISQLKQKLENLQNSQLPESFRVPY
DPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNET
IGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPY
GCISTGDKIGMIEIVKDATTIAKIQQSTFKDEVLNHWLKE
KSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIM
ITETGNLFHIDFGHERVPFVLTPDFLFVMGTSGKKTSPHF
QKFQDICVKAYLALRHHTNLLIILFSMMLMTDIEYIRDAL
TVGKNEEDAKKYFLDQIEVCRDKGWTVQF
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Description
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Functional site
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|
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1)
|
chain |
A |
| residue |
647 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE GNP C 2
|
| source |
: AC2
|
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2)
|
chain |
A |
| residue |
832-846 |
| type |
prosite |
| sequence |
FKHGDDLRQDMLILQ
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| description |
PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
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| source |
prosite : PS00915
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3)
|
chain |
A |
| residue |
931-951 |
| type |
prosite |
| sequence |
SCAGYCVATFVLGIGDRHNDN
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| description |
PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
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| source |
prosite : PS00916
|
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4)
|
chain |
A |
| residue |
962 |
| type |
BINDING |
| sequence |
H
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
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