eF-site ID 1hdb-B
PDB Code 1hdb
Chain B

click to enlarge
Title ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN
Classification OXYGEN TRANSPORT
Compound HEMOGLOBIN (DEOXY) BETA-V67T
Source Homo sapiens (Human) (HBB_HUMAN)
Sequence B:  VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQR
FFESFGDLSTPDAVMGNPKVKAHGKKTLGAFSDGLAHLDN
LKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGK
EFTPPVQAAYQKVVAGVANALAHKYH
Description


Functional site
1) chain B
residue 1
type
sequence V
description BINDING SITE FOR RESIDUE SO4 B 147
source : AC2
2) chain B
residue 78
type
sequence L
description BINDING SITE FOR RESIDUE SO4 B 147
source : AC2
3) chain B
residue 81
type
sequence L
description BINDING SITE FOR RESIDUE SO4 B 147
source : AC2
4) chain B
residue 82
type
sequence K
description BINDING SITE FOR RESIDUE SO4 B 147
source : AC2
5) chain B
residue 41
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
6) chain B
residue 42
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
7) chain B
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
8) chain B
residue 67
type
sequence T
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
9) chain B
residue 91
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
10) chain B
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
11) chain B
residue 96
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
12) chain B
residue 102
type
sequence N
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
13) chain B
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
14) chain B
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 148
source : AC4
15) chain B
residue 2
type CARBOHYD
sequence H
description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
source Swiss-Prot : SWS_FT_FI12
16) chain B
residue 9
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
17) chain B
residue 18
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
18) chain B
residue 67
type CARBOHYD
sequence T
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
19) chain B
residue 121
type CARBOHYD
sequence E
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
20) chain B
residue 145
type CARBOHYD
sequence Y
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI14
21) chain B
residue 2
type MOD_RES
sequence H
description N-pyruvate 2-iminyl-valine; in Hb A1b
source Swiss-Prot : SWS_FT_FI3
22) chain B
residue 13
type MOD_RES
sequence A
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI4
23) chain B
residue 51
type MOD_RES
sequence P
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI4
24) chain B
residue 88
type MOD_RES
sequence L
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI4
25) chain B
residue 45
type MOD_RES
sequence F
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI5
26) chain B
residue 10
type MOD_RES
sequence A
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI5
27) chain B
residue 60
type MOD_RES
sequence V
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI6
28) chain B
residue 83
type MOD_RES
sequence G
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI6
29) chain B
residue 94
type MOD_RES
sequence D
description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
source Swiss-Prot : SWS_FT_FI7
30) chain B
residue 2
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI9
31) chain B
residue 3
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI9
32) chain B
residue 83
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI9
33) chain B
residue 144
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI9
34) chain B
residue 145
type MOD_RES
sequence Y
description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI8
35) chain B
residue 8
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
36) chain B
residue 75
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
37) chain B
residue 85
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
38) chain B
residue 93
type SITE
sequence C
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
39) chain B
residue 105
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
40) chain B
residue 111
type SITE
sequence V
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
41) chain B
residue 120
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
42) chain B
residue 123
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
43) chain B
residue 129
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
44) chain B
residue 141
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
45) chain B
residue 145
type SITE
sequence Y
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
46) chain B
residue 26
type SITE
sequence E
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
47) chain B
residue 30
type SITE
sequence R
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
48) chain B
residue 36
type SITE
sequence P
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
49) chain B
residue 38
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
50) chain B
residue 46
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
51) chain B
residue 53
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
52) chain B
residue 57
type SITE
sequence N
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
53) chain B
residue 72
type SITE
sequence S
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI10
54) chain B
residue 60
type SITE
sequence V
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI11
55) chain B
residue 83
type SITE
sequence G
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI11
56) chain B
residue 96
type SITE
sequence L
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI11
57) chain B
residue 64
type BINDING
sequence G
description distal binding residue
source Swiss-Prot : SWS_FT_FI1
58) chain B
residue 93
type BINDING
sequence C
description proximal binding residue
source Swiss-Prot : SWS_FT_FI2

Display surface

Download
Links