eF-site ID 1hdb-A PDB Code 1hdb Chain A click to enlarge Title ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN Classification OXYGEN TRANSPORT Compound HEMOGLOBIN (DEOXY) BETA-V67T Source Homo sapiens (Human) (HBB_HUMAN) Sequence A:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR Description Functional site 1) chain A residue 42 type sequence Y description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 2) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 3) chain A residue 46 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 4) chain A residue 58 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 5) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 6) chain A residue 87 type sequence H description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 7) chain A residue 91 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 8) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 9) chain A residue 97 type sequence N description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 10) chain A residue 98 type sequence F description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 11) chain A residue 136 type sequence L description BINDING SITE FOR RESIDUE HEM A 142 source : AC3 12) chain A residue 53 type sequence A description BINDING SITE FOR RESIDUE HEM B 148 source : AC4 13) chain A residue 41 type CARBOHYD sequence T description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI12 14) chain A residue 50 type MOD_RES sequence H description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI3 15) chain A residue 132 type MOD_RES sequence V description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI8 16) chain A residue 139 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI8

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