eF-site ID 1hcq-EFGH PDB Code 1hcq Chain E, F, G, H click to enlarge Title THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS Classification TRANSCRIPTION/DNA Compound DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3') Source Homo sapiens (Human) (1HCQ) Sequence E:  MKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHND YMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMK F:  KETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGDYMC PATNQCTIDKNRRKSCQACRLRKCYEVGMMK G:  CCAGGTCACAGTGACCTG H:  CCAGGTCACTGTGACCTG Description Functional site 1) chain E residue 7 type sequence C description BINDING SITE FOR RESIDUE ZN E 598 source : AC5 2) chain E residue 10 type sequence C description BINDING SITE FOR RESIDUE ZN E 598 source : AC5 3) chain E residue 24 type sequence C description BINDING SITE FOR RESIDUE ZN E 598 source : AC5 4) chain E residue 27 type sequence C description BINDING SITE FOR RESIDUE ZN E 598 source : AC5 5) chain E residue 43 type sequence C description BINDING SITE FOR RESIDUE ZN E 599 source : AC6 6) chain E residue 49 type sequence C description BINDING SITE FOR RESIDUE ZN E 599 source : AC6 7) chain E residue 59 type sequence C description BINDING SITE FOR RESIDUE ZN E 599 source : AC6 8) chain E residue 62 type sequence C description BINDING SITE FOR RESIDUE ZN E 599 source : AC6 9) chain F residue 7 type sequence C description BINDING SITE FOR RESIDUE ZN F 598 source : AC7 10) chain F residue 10 type sequence C description BINDING SITE FOR RESIDUE ZN F 598 source : AC7 11) chain F residue 24 type sequence C description BINDING SITE FOR RESIDUE ZN F 598 source : AC7 12) chain F residue 27 type sequence C description BINDING SITE FOR RESIDUE ZN F 598 source : AC7 13) chain F residue 43 type sequence C description BINDING SITE FOR RESIDUE ZN F 599 source : AC8 14) chain F residue 44 type sequence P description BINDING SITE FOR RESIDUE ZN F 599 source : AC8 15) chain F residue 49 type sequence C description BINDING SITE FOR RESIDUE ZN F 599 source : AC8 16) chain F residue 59 type sequence C description BINDING SITE FOR RESIDUE ZN F 599 source : AC8 17) chain F residue 62 type sequence C description BINDING SITE FOR RESIDUE ZN F 599 source : AC8 18) chain E residue 7-72 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPAT NQCTIDKNRRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 19) chain F residue 7-72 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGDYMCPATNQ CTIDKNRRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 20) chain E residue 7-27 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 21) chain E residue 43-67 type ZN_FING sequence CPATNQCTIDKNRRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 22) chain F residue 7-27 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 23) chain F residue 43-67 type ZN_FING sequence CPATNQCTIDKNRRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2

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