eF-site ID 1hb0-B PDB Code 1hb0 Chain B click to enlarge Title Snapshots of serine protease catalysis: (D) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 jumped to pH 10 for 2 minutes Classification HYDROLASE Compound ELASTASE 1 Source ORGANISM_COMMON: PIG; ORGANISM_SCIENTIFIC: SUS SCROFA; Sequence B:  VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWV MTAAHCVDRELTFRVVVGEHNLNQNNGTEQYVGVQKIVVH PYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTI LRNNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSS SSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQY AVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN Description Functional site 1) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE CA B1246 source : AC1 2) chain B residue 72 type sequence N description BINDING SITE FOR RESIDUE CA B1246 source : AC1 3) chain B residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA B1246 source : AC1 4) chain B residue 77 type sequence N description BINDING SITE FOR RESIDUE CA B1246 source : AC1 5) chain B residue 80 type sequence E description BINDING SITE FOR RESIDUE CA B1246 source : AC1 6) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE SO4 B1247 source : AC2 7) chain B residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 B1247 source : AC2 8) chain B residue 230 type sequence R description BINDING SITE FOR RESIDUE SO4 B1247 source : AC2 9) chain B residue 232 type sequence S description BINDING SITE FOR RESIDUE SO4 B1247 source : AC2 10) chain B residue 233 type sequence A description BINDING SITE FOR RESIDUE SO4 B1247 source : AC2 11) chain B residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:4578945, ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000269|PubMed:5415110 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 53-58 type prosite sequence MTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC source prosite : PS00134 15) chain B residue 189-200 type prosite sequence SGCQGDSGGPLH description TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH source prosite : PS00135 16) chain B residue 70 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 17) chain B residue 80 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 18) chain B residue 72 type BINDING sequence N description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3 19) chain B residue 75 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:7656008, ECO:0007744|PDB:1ELA, ECO:0007744|PDB:1ELB, ECO:0007744|PDB:1ELC source Swiss-Prot : SWS_FT_FI3

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