eF-site ID 1h9u-ABCD PDB Code 1h9u Chain A, B, C, D click to enlarge Title The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268 Classification NUCLEAR RECEPTOR Compound RETINOID X RECEPTOR, BETA Source null (RXRB_HUMAN) Sequence A:  MPVDRILEAELAVPVTNICQAADKQLFTLVEWAKRIPHFS SLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL HVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCL RAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF L B:  MPVDRILEAELAVPVTNICQAADKQLFTLVEWAKRIPHFS SLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL HVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCL RAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF L C:  MPVDRILEAELAVPVTNICQAADKQLFTLVEWAKRIPHFS SLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL HVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCL RAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF L D:  MPVDRILEAELAVPVTNICQAADKQLFTLVEWAKRIPHFS SLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL HVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCL RAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF L Description Functional site 1) chain A residue 402 type sequence H description BINDING SITE FOR RESIDUE NI A 2 source : AC1 2) chain A residue 404 type sequence H description BINDING SITE FOR RESIDUE NI A 2 source : AC1 3) chain A residue 404 type sequence H description BINDING SITE FOR RESIDUE CL A 3 source : AC2 4) chain B residue 402 type sequence H description BINDING SITE FOR RESIDUE NI B 2 source : AC3 5) chain B residue 404 type sequence H description BINDING SITE FOR RESIDUE NI B 2 source : AC3 6) chain B residue 404 type sequence H description BINDING SITE FOR RESIDUE CL B 3 source : AC4 7) chain C residue 402 type sequence H description BINDING SITE FOR RESIDUE NI C 2 source : AC5 8) chain C residue 404 type sequence H description BINDING SITE FOR RESIDUE NI C 2 source : AC5 9) chain D residue 402 type sequence H description BINDING SITE FOR RESIDUE NI D 2 source : AC6 10) chain D residue 404 type sequence H description BINDING SITE FOR RESIDUE NI D 2 source : AC6 11) chain A residue 339 type sequence I description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 12) chain A residue 342 type sequence A description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 13) chain A residue 343 type sequence A description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 14) chain A residue 346 type sequence Q description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 15) chain A residue 376 type sequence W description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 16) chain A residue 380 type sequence L description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 17) chain A residue 381 type sequence I description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 18) chain A residue 384 type sequence F description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 19) chain A residue 387 type sequence R description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 20) chain A residue 397 type sequence L description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 21) chain A residue 398 type sequence A description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 22) chain A residue 416 type sequence I description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 23) chain A residue 503 type sequence C description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 24) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE LG2 A 1 source : AC7 25) chain B residue 339 type sequence I description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 26) chain B residue 342 type sequence A description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 27) chain B residue 343 type sequence A description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 28) chain B residue 346 type sequence Q description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 29) chain B residue 380 type sequence L description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 30) chain B residue 381 type sequence I description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 31) chain B residue 384 type sequence F description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 32) chain B residue 387 type sequence R description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 33) chain B residue 397 type sequence L description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 34) chain B residue 398 type sequence A description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 35) chain B residue 416 type sequence I description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 36) chain B residue 503 type sequence C description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 37) chain B residue 506 type sequence H description BINDING SITE FOR RESIDUE LG2 B 1 source : AC8 38) chain C residue 339 type sequence I description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 39) chain C residue 342 type sequence A description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 40) chain C residue 343 type sequence A description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 41) chain C residue 346 type sequence Q description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 42) chain C residue 376 type sequence W description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 43) chain C residue 380 type sequence L description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 44) chain C residue 381 type sequence I description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 45) chain C residue 387 type sequence R description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 46) chain C residue 397 type sequence L description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 47) chain C residue 398 type sequence A description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 48) chain C residue 503 type sequence C description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 49) chain C residue 506 type sequence H description BINDING SITE FOR RESIDUE LG2 C 1 source : AC9 50) chain D residue 339 type sequence I description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 51) chain D residue 342 type sequence A description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 52) chain D residue 343 type sequence A description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 53) chain D residue 346 type sequence Q description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 54) chain D residue 376 type sequence W description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 55) chain D residue 380 type sequence L description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 56) chain D residue 381 type sequence I description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 57) chain D residue 384 type sequence F description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 58) chain D residue 387 type sequence R description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 59) chain D residue 397 type sequence L description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 60) chain D residue 398 type sequence A description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 61) chain D residue 416 type sequence I description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 62) chain D residue 503 type sequence C description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1 63) chain D residue 506 type sequence H description BINDING SITE FOR RESIDUE LG2 D 1 source : BC1

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