eF-site ID 1h8x-AB PDB Code 1h8x Chain A, B click to enlarge Title Domain-swapped Dimer of a Human Pancreatic Ribonuclease Variant Classification HYDROLASE Compound RIBONUCLEASE 1 Source Homo sapiens (Human) (RNP_HUMAN) Sequence A:  KESAAAKFERQHMDSGNSPSSSSTYCNQMMRRRNMTQGRC KPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMH ITDCRLTNGSRYPNCAYRTSQKERHIIVACEGSPYVPVHF DASVED B:  KESAAAKFERQHMDSGNSPSSSSTYCNQMMRRRNMTQGRC KPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMH ITDCRLTNGSRYPNCAYRTSQKERHIIVACEGSPYVPVHF DASVED Description Functional site 1) chain A residue 140-146 type prosite sequence CKPVNTF description RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF source prosite : PS00127 2) chain A residue 112 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 3) chain B residue 112 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 4) chain A residue 219 type ACT_SITE sequence H description Proton donor source Swiss-Prot : SWS_FT_FI2 5) chain B residue 219 type ACT_SITE sequence H description Proton donor source Swiss-Prot : SWS_FT_FI2 6) chain A residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 7) chain B residue 185 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 110 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 141 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 166 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 185 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 110 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 141 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 166 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 134 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 134 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 188 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI5 20) chain B residue 176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI5 21) chain B residue 188 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829 source Swiss-Prot : SWS_FT_FI5

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