eF-site ID 1h7a-A PDB Code 1h7a Chain A click to enlarge Title Structural basis for allosteric substrate specificity regulation in class III ribonucleotide reductases: NRDD in complex with dATP Classification OXIDOREDUCTASE Compound ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN Source (Q9T0V5) Sequence A:  SRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHESGIIHVH DIDYSPALPFTNCCLVDLKGMLENGFKLGNAQIETPKSIG VATAIMAQITAQVASHQYGGTTFANVDKVLSPYVKRTYAK HIEDAEKWQIADALNYAQSKTEKDVYDAFQAYEYEVNTLF SSNGQTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRDG ITPIFPKLVMFVEEGVNLYKDDPNYDIKQLALECASKRMY PDIISAKNNKAITGSSVPVSPMGCRSFLSVWKDSTGNEIL DGRNNLGVVTLNLPRIALDSYIGTQFNEQKFVELFNERMD LCFEALMCRISSLKGVKATVAPILYQEGAFGVRLKPDDDI IELFKNGRSSVSLGYIGIHELNILVGRDIGREILTKMNAH LKQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDV TDKGWYTNSFHVSVEENITPFEKISREAPYHFIATGGHIS YVELPDMKNNLKGLEAVWDYAAQHLDYFGVNMPVDKCFTC GSTHEMTPTENGFVCSICGETDPKKMNTIRRTCAYLGNPN ERG Description Functional site 1) chain A residue 543 type sequence C description BINDING SITE FOR RESIDUE FE2 A1591 source : AC1 2) chain A residue 546 type sequence C description BINDING SITE FOR RESIDUE FE2 A1591 source : AC1 3) chain A residue 561 type sequence C description BINDING SITE FOR RESIDUE FE2 A1591 source : AC1 4) chain A residue 564 type sequence C description BINDING SITE FOR RESIDUE FE2 A1591 source : AC1 5) chain A residue 566 type sequence E description BINDING SITE FOR RESIDUE FE2 A1591 source : AC1 6) chain A residue 99 type sequence I description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 7) chain A residue 100 type sequence E description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 8) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 9) chain A residue 107 type sequence V description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 10) chain A residue 114 type sequence Q description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 11) chain A residue 146 type sequence K description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 12) chain A residue 169 type sequence K description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 13) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 14) chain A residue 176 type sequence Q description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 15) chain A residue 177 type sequence A description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 16) chain A residue 180 type sequence Y description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 17) chain A residue 181 type sequence E description BINDING SITE FOR RESIDUE DTP A1590 source : AC3 18) chain A residue 78 type catalytic sequence N description 416 source MCSA : MCSA1 19) chain A residue 79 type catalytic sequence C description 416 source MCSA : MCSA1 20) chain A residue 288 type catalytic sequence M description 416 source MCSA : MCSA1 21) chain A residue 290 type catalytic sequence C description 416 source MCSA : MCSA1 22) chain A residue 292 type catalytic sequence S description 416 source MCSA : MCSA1 23) chain A residue 311 type catalytic sequence N description 416 source MCSA : MCSA1 24) chain A residue 441 type catalytic sequence Y description 416 source MCSA : MCSA1 25) chain A residue 446 type catalytic sequence E description 416 source MCSA : MCSA1 26) chain A residue 580 type catalytic sequence A description 416 source MCSA : MCSA1 27) chain A residue 64 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 66 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 67 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 103 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 447 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 448 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12655046, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 100 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11587648, ECO:0007744|PDB:1H79 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 114 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:11587648, ECO:0007744|PDB:1H79 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 146 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11587648, ECO:0007744|PDB:1H79 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 445 type BINDING sequence A description BINDING => ECO:0000269|PubMed:11587648, ECO:0007744|PDB:1H78 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 543 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12655046, ECO:0000305|PubMed:11587648, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 546 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12655046, ECO:0000305|PubMed:11587648, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 561 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12655046, ECO:0000305|PubMed:11587648, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 564 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12655046, ECO:0000305|PubMed:11587648, ECO:0007744|PDB:1HK8 source Swiss-Prot : SWS_FT_FI4 41) chain A residue 580 type MOD_RES sequence A description Glycine radical => ECO:0000269|PubMed:8702830 source Swiss-Prot : SWS_FT_FI5

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