eF-site ID 1h4j-ABCDEFGH PDB Code 1h4j Chain A, B, C, D, E, F, G, H click to enlarge Title Methylobacterium extorquens methanol dehydrogenase D303E mutant Classification OXIDOREDUCTASE Compound Methanol dehydrogenase [cytochrome c] subunit 1 Source (DHM2_METEA) Sequence A:  NDKLVELSKSDDNWVMPGKNYDSNNFSDLKQINKGNVKQL RPAWTFSTGLLNGHEGAPLVVDGKMYIHTSFPNNTFALGL DDPGTILWQDKPKQNPAARAVACCDLVNRGLAYWPGDGKT PALILKTQLDGNVAALNAETGETVWKVENSDIKVGSTLTI APYVVKDKVIIGSSGAELGVRGYLTAYDVKTGEQVWRAYA TGPDKDLLLASDFNIKNPHYGQKGLGTGTWEGDAWKIGGG TNWGWYAYDPGTNLIYFGTGNPAPWNETMRPGDNKWTMTI FGRDADTGEAKFGYQKTPHDEWEYAGVNVMMLSEQKDKDG KARKLLTHPDRNGIVYTLDRTDGALVSANKLDDTVNVFKS VDLKTGQPVRDPEYGTRMDHLAKDICPSAMGYHNQGHDSY DPKRELFFMGINHICMDWEPFMLPYRAGQFFVGATLNMYP GPKGDRQNYEGLGQIKAYNAITGDYKWEKMERFAVWGGTM ATAGDLVFYGTLDGYLKARDSDTGDLLWKFKIPSGAIGYP MTYTHKGTQYVAIYYGVGGWPGVGLVFDLADPTAGLGAVG AFKKLANYTQMGGGVVVFSLDGKGPYDDPNVGEWK B:  YDGTKCKAAGNCWEPKPGFPEKIAGSKYDPKHDPKELNKQ ADSIKQMEERNKKRVENFKKTGKFEYDVAKIS C:  NDKLVELSKSDDNWVMPGKNYDSNNFSDLKQINKGNVKQL RPAWTFSTGLLNGHEGAPLVVDGKMYIHTSFPNNTFALGL DDPGTILWQDKPKQNPAARAVACCDLVNRGLAYWPGDGKT PALILKTQLDGNVAALNAETGETVWKVENSDIKVGSTLTI APYVVKDKVIIGSSGAELGVRGYLTAYDVKTGEQVWRAYA TGPDKDLLLASDFNIKNPHYGQKGLGTGTWEGDAWKIGGG TNWGWYAYDPGTNLIYFGTGNPAPWNETMRPGDNKWTMTI FGRDADTGEAKFGYQKTPHDEWEYAGVNVMMLSEQKDKDG KARKLLTHPDRNGIVYTLDRTDGALVSANKLDDTVNVFKS VDLKTGQPVRDPEYGTRMDHLAKDICPSAMGYHNQGHDSY DPKRELFFMGINHICMDWEPFMLPYRAGQFFVGATLNMYP GPKGDRQNYEGLGQIKAYNAITGDYKWEKMERFAVWGGTM ATAGDLVFYGTLDGYLKARDSDTGDLLWKFKIPSGAIGYP MTYTHKGTQYVAIYYGVGGWPGVGLVFDLADPTAGLGAVG AFKKLANYTQMGGGVVVFSLDGKGPYDDPNVGEWK D:  YDGTKCKAAGNCWEPKPGFPEKIAGSKYDPKHDPKELNKQ ADSIKQMEERNKKRVENFKKTGKFEYDVAKIS E:  NDKLVELSKSDDNWVMPGKNYDSNNFSDLKQINKGNVKQL RPAWTFSTGLLNGHEGAPLVVDGKMYIHTSFPNNTFALGL DDPGTILWQDKPKQNPAARAVACCDLVNRGLAYWPGDGKT PALILKTQLDGNVAALNAETGETVWKVENSDIKVGSTLTI APYVVKDKVIIGSSGAELGVRGYLTAYDVKTGEQVWRAYA TGPDKDLLLASDFNIKNPHYGQKGLGTGTWEGDAWKIGGG TNWGWYAYDPGTNLIYFGTGNPAPWNETMRPGDNKWTMTI FGRDADTGEAKFGYQKTPHDEWEYAGVNVMMLSEQKDKDG KARKLLTHPDRNGIVYTLDRTDGALVSANKLDDTVNVFKS VDLKTGQPVRDPEYGTRMDHLAKDICPSAMGYHNQGHDSY DPKRELFFMGINHICMDWEPFMLPYRAGQFFVGATLNMYP GPKGDRQNYEGLGQIKAYNAITGDYKWEKMERFAVWGGTM ATAGDLVFYGTLDGYLKARDSDTGDLLWKFKIPSGAIGYP MTYTHKGTQYVAIYYGVGGWPGVGLVFDLADPTAGLGAVG AFKKLANYTQMGGGVVVFSLDGKGPYDDPNVGEWK F:  YDGTKCKAAGNCWEPKPGFPEKIAGSKYDPKHDPKELNKQ ADSIKQMEERNKKRVENFKKTGKFEYDVAKIS G:  NDKLVELSKSDDNWVMPGKNYDSNNFSDLKQINKGNVKQL RPAWTFSTGLLNGHEGAPLVVDGKMYIHTSFPNNTFALGL DDPGTILWQDKPKQNPAARAVACCDLVNRGLAYWPGDGKT PALILKTQLDGNVAALNAETGETVWKVENSDIKVGSTLTI APYVVKDKVIIGSSGAELGVRGYLTAYDVKTGEQVWRAYA TGPDKDLLLASDFNIKNPHYGQKGLGTGTWEGDAWKIGGG TNWGWYAYDPGTNLIYFGTGNPAPWNETMRPGDNKWTMTI FGRDADTGEAKFGYQKTPHDEWEYAGVNVMMLSEQKDKDG KARKLLTHPDRNGIVYTLDRTDGALVSANKLDDTVNVFKS VDLKTGQPVRDPEYGTRMDHLAKDICPSAMGYHNQGHDSY DPKRELFFMGINHICMDWEPFMLPYRAGQFFVGATLNMYP GPKGDRQNYEGLGQIKAYNAITGDYKWEKMERFAVWGGTM ATAGDLVFYGTLDGYLKARDSDTGDLLWKFKIPSGAIGYP MTYTHKGTQYVAIYYGVGGWPGVGLVFDLADPTAGLGAVG AFKKLANYTQMGGGVVVFSLDGKGPYDDPNVGEWK H:  YDGTKCKAAGNCWEPKPGFPEKIAGSKYDPKHDPKELNKQ ADSIKQMEERNKKRVENFKKTGKFEYDVAKIS Description (1)  METHANOL DEHYDROGENASE SUBUNIT 1, METHANOL DEHYDROGENASE SUBUNIT 2 (E.C.1.1.99.8) Functional site 1) chain A residue 177 type sequence E description BINDING SITE FOR RESIDUE CA A 701 source : AC1 2) chain A residue 261 type sequence N description BINDING SITE FOR RESIDUE CA A 701 source : AC1 3) chain A residue 303 type sequence E description BINDING SITE FOR RESIDUE CA A 701 source : AC1 4) chain C residue 177 type sequence E description BINDING SITE FOR RESIDUE CA C 701 source : AC2 5) chain C residue 261 type sequence N description BINDING SITE FOR RESIDUE CA C 701 source : AC2 6) chain C residue 303 type sequence E description BINDING SITE FOR RESIDUE CA C 701 source : AC2 7) chain E residue 177 type sequence E description BINDING SITE FOR RESIDUE CA E 701 source : AC3 8) chain E residue 261 type sequence N description BINDING SITE FOR RESIDUE CA E 701 source : AC3 9) chain E residue 303 type sequence E description BINDING SITE FOR RESIDUE CA E 701 source : AC3 10) chain G residue 177 type sequence E description BINDING SITE FOR RESIDUE CA G 701 source : AC4 11) chain G residue 261 type sequence N description BINDING SITE FOR RESIDUE CA G 701 source : AC4 12) chain G residue 303 type sequence E description BINDING SITE FOR RESIDUE CA G 701 source : AC4 13) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 14) chain A residue 104 type sequence C description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 15) chain A residue 107 type sequence V description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 16) chain A residue 109 type sequence R description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 17) chain A residue 159 type sequence T description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 18) chain A residue 174 type sequence S description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 19) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 20) chain A residue 176 type sequence A description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 21) chain A residue 177 type sequence E description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 22) chain A residue 241 type sequence T description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 23) chain A residue 243 type sequence W description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 24) chain A residue 261 type sequence N description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 25) chain A residue 303 type sequence E description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 26) chain A residue 331 type sequence R description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 27) chain A residue 394 type sequence N description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 28) chain A residue 476 type sequence W description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 29) chain A residue 539 type sequence G description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 30) chain A residue 540 type sequence W description BINDING SITE FOR RESIDUE PQQ A 601 source : AC5 31) chain C residue 55 type sequence E description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 32) chain C residue 104 type sequence C description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 33) chain C residue 107 type sequence V description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 34) chain C residue 109 type sequence R description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 35) chain C residue 159 type sequence T description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 36) chain C residue 174 type sequence S description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 37) chain C residue 175 type sequence G description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 38) chain C residue 176 type sequence A description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 39) chain C residue 177 type sequence E description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 40) chain C residue 241 type sequence T description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 41) chain C residue 243 type sequence W description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 42) chain C residue 261 type sequence N description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 43) chain C residue 303 type sequence E description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 44) chain C residue 331 type sequence R description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 45) chain C residue 394 type sequence N description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 46) chain C residue 476 type sequence W description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 47) chain C residue 539 type sequence G description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 48) chain C residue 540 type sequence W description BINDING SITE FOR RESIDUE PQQ C 601 source : AC6 49) chain E residue 55 type sequence E description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 50) chain E residue 104 type sequence C description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 51) chain E residue 107 type sequence V description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 52) chain E residue 109 type sequence R description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 53) chain E residue 159 type sequence T description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 54) chain E residue 174 type sequence S description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 55) chain E residue 175 type sequence G description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 56) chain E residue 176 type sequence A description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 57) chain E residue 177 type sequence E description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 58) chain E residue 241 type sequence T description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 59) chain E residue 243 type sequence W description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 60) chain E residue 261 type sequence N description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 61) chain E residue 303 type sequence E description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 62) chain E residue 331 type sequence R description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 63) chain E residue 394 type sequence N description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 64) chain E residue 476 type sequence W description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 65) chain E residue 539 type sequence G description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 66) chain E residue 540 type sequence W description BINDING SITE FOR RESIDUE PQQ E 601 source : AC7 67) chain G residue 55 type sequence E description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 68) chain G residue 104 type sequence C description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 69) chain G residue 107 type sequence V description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 70) chain G residue 109 type sequence R description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 71) chain G residue 159 type sequence T description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 72) chain G residue 174 type sequence S description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 73) chain G residue 175 type sequence G description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 74) chain G residue 176 type sequence A description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 75) chain G residue 177 type sequence E description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 76) chain G residue 241 type sequence T description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 77) chain G residue 243 type sequence W description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 78) chain G residue 261 type sequence N description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 79) chain G residue 303 type sequence E description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 80) chain G residue 331 type sequence R description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 81) chain G residue 394 type sequence N description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 82) chain G residue 476 type sequence W description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 83) chain G residue 539 type sequence G description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 84) chain G residue 540 type sequence W description BINDING SITE FOR RESIDUE PQQ G 601 source : AC8 85) chain A residue 13-41 type prosite sequence NWVMPGKNYDSNNFSDLKQINKGNVKQLR description BACTERIAL_PQQ_1 Bacterial quinoprotein dehydrogenases signature 1. NWvmpGKnydsnnFSdlkqINkgNVkqLR source prosite : PS00363 86) chain A residue 243-264 type prosite sequence WGWYAYDPGTNLIYFGTGNPAP description BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpgtNLIYFgtGnpAP source prosite : PS00364 87) chain A residue 177 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 88) chain A residue 261 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 89) chain C residue 177 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 90) chain C residue 261 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 91) chain E residue 177 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 92) chain E residue 261 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 93) chain G residue 177 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 94) chain G residue 261 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 95) chain A residue 303 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 96) chain C residue 303 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 97) chain E residue 303 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 98) chain G residue 303 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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