eF-site ID 1h3i-B PDB Code 1h3i Chain B click to enlarge Title Crystal structure of the Histone Methyltransferase SET7/9 Classification TRANSFERASE Compound HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE Source Homo sapiens (Human) (Q8WTS6) Sequence B:  FFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGEL NGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVG EVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLAT LMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPY ESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRIT HQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASL GHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEEL TVAYGYDHSPPGK Description (1)  HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE (E.C.2.1.1.43) Functional site 1) chain B residue 279 type sequence E description BINDING SITE FOR RESIDUE MG A1346 source : AC2 2) chain B residue 283 type sequence H description BINDING SITE FOR RESIDUE MG A1346 source : AC2 3) chain B residue 191 type catalytic sequence Y description 350 source MCSA : MCSA2 4) chain B residue 239 type catalytic sequence N description 350 source MCSA : MCSA2 5) chain B residue 243 type catalytic sequence S description 350 source MCSA : MCSA2 6) chain B residue 251 type catalytic sequence T description 350 source MCSA : MCSA2 7) chain B residue 281 type catalytic sequence Y description 350 source MCSA : MCSA2 8) chain B residue 302 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 281 type SITE sequence Y description Histone H3K4 binding => ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 191 type SITE sequence Y description Histone H3K4 binding => ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 202 type SITE sequence S description Histone H3K4 binding => ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 212 type SITE sequence E description Histone H3K4 binding => ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 263 type SITE sequence N description Histone H3K4 binding => ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 172 type BINDING sequence L description BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 242 type BINDING sequence M description BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 243 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links